Sandbox Reserved 1092: Difference between revisions
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=5JI1 : Myostatin (GDF8)= | =5JI1 : Myostatin (GDF8)= | ||
In ’’’1997’’’, myostatin was discovered by McPherron who demonstrated that a phenotype of exaggerated muscle hypertrophy correlated with mutations in the myostatin gene. It was at first associated with the role it played in the regulation of muscular mass of mice. This new growing factor has been, since then, completely sequenced, and the primary sequences, obtained in different animals, have been put in comparison. The results showed that there were an important correlation between the sequences, whatever their origin. <ref name="Structure and synthesis"> Université de Montpellier. Physiologie expérimentale du coeur et des muscles : la myostatine/partenaires de la myostatine. [https://u1046.edu.umontpellier.fr/163-2/abrege-des-proteines-musculaires/myostatine/]</ref> | |||
==Classification== | |||
This protein was firstly named ’’’Growth/Differentiation Factor 8 (GDF8)’’’ because it belongs to the group of growth factors. Growth factors constitute a group of proteins that regulate the number of cells, increasing or decreasing their multiplication according to the needs. Then the nomenclature changed and we refer to myostatine as MSTN. Progressively, the myostatin has been affiliated to the TGF-beta family (transforming growth factor beta). | |||
= Function = | = Function = | ||
= Structure and synthesis <ref name="Structure and synthesis"> Université de Montpellier. Physiologie expérimentale du coeur et des muscles : la myostatine/partenaires de la myostatine. [https://u1046.edu.umontpellier.fr/163-2/abrege-des-proteines-musculaires/myostatine/]</ref> = | = Structure and synthesis <ref name="Structure and synthesis"> Université de Montpellier. Physiologie expérimentale du coeur et des muscles : la myostatine/partenaires de la myostatine. [https://u1046.edu.umontpellier.fr/163-2/abrege-des-proteines-musculaires/myostatine/]</ref> = | ||
