Sandbox Reserved 1106: Difference between revisions
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Besides, Argonaute 1 can be found in a lot of phylogenetic groups, with different structure. For example, in the plant ''Brachypodium distachyon'', where 10 argonautes proteins have been discovered, BdAGO1 lacks the N and Mid domains. This particularity explains the small size of this protein with only 624 residues. Moreover, BdAGO1 is functionally related to Ago1 as both proteins lack endonuclease activity. Indeed, the catalytic tetrad of its PIWI domain is disabled through the absence of the last D/H residue in the domain. | Besides, Argonaute 1 can be found in a lot of phylogenetic groups, with different structure. For example, in the plant ''Brachypodium distachyon'', where 10 argonautes proteins have been discovered, BdAGO1 lacks the N and Mid domains. This particularity explains the small size of this protein with only 624 residues. Moreover, BdAGO1 is functionally related to Ago1 as both proteins lack endonuclease activity. Indeed, the catalytic tetrad of its PIWI domain is disabled through the absence of the last D/H residue in the domain. | ||
However, the AtAGO1 (from ''Arabidopsis thaliana''), which can be found in the nucleus and the cytoplasm of the plant, includes a Mid domain and has an homologous conformation to BdAO9, BdAGO11, BdAGO12, BdAGO15, and BdAGO16. On the other hand, BdAGO1 has AtAGO4 as its closest homolog (like BaAGO2, BdAGO3 and BdAGO4), even if the AtAGO4 possess a Mid Domain. | However, the AtAGO1 (from ''Arabidopsis thaliana''), which can be found in the nucleus and the cytoplasm of the plant, includes a Mid domain and has an homologous conformation to BdAO9, BdAGO11, BdAGO12, BdAGO15, and BdAGO16. On the other hand, BdAGO1 has AtAGO4 as its closest homolog (like BaAGO2, BdAGO3 and BdAGO4), even if the AtAGO4 possess a Mid Domain. <ref name="source1"> Ena Secic, et al. (2019, October). ''Further Elucidation of the argonaute and dicer protein families in the model grass species Brachypodium distachyon''. Frontiers in Plant Science.</ref> | ||
==== Proteins Associating with Ago1 ==== | ==== Proteins Associating with Ago1 ==== | ||
