Sandbox Reserved 1091: Difference between revisions

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The '''structure of ASP''' is very similar to that of ''Kex2'' ([[1r64]]), but it has a unique extra-occluding region close to its active site within the subtilisin domains. This extra-occluding region is unique and it could serve as a useful target to make the development of new antisepsis drugs easier.

The '''domain structure of ASP''' consists of the propeptide, the catalytic subtilisin-like domain, and the P-domain. The ASP molecule have two mean regions: an N-terminal region extending from Gly-3 to Pro-431 and forming the <scene name='82/829344/The_subtilisin_domain/1'>subtilisin domain</scene>, and a C-terminal region extending from Leu-432 to His-595 and forming the <scene name='82/829344/The_p-domain/2'>P-domain</scene>.

The '''domain structure of ASP''' consists of the propeptide, the catalytic subtilisin-like domain, and the P-domain. The ASP molecule have two mean regions: an N-terminal region extending from Gly-3 to Pro-431 and forming the <scene name='82/829344/The_subtilisin_domain/2'>subtilisin domain</scene>, and a C-terminal region extending from Leu-432 to His-595 and forming the <scene name='82/829344/The_p-domain/2'>P-domain</scene>.

Moreover, we can find three <scene name='82/829344/Calcium_binding_sites/2'>Ca2+ Binding Sites</scene> in the ASP Structure (Ca1, Ca2 and Ca3). <scene name='82/829344/Ca1_et_ca2/1'>Ca1 and Ca2</scene> are situated in the N-terminal domain, and <scene name='82/829344/Ca3/1'>Ca3</scene> is situated in the C-terminal domain. It were assigned to ASP based on electron density, counter charges, and coordination. But in contrary to ''Kex2'', ASP contains no Ca2+ binding sites near its catalytic site. Those Ca2+ binding Site are important because ...

Moreover, we can find three <scene name='82/829344/Calcium_binding_sites/2'>Ca2+ Binding Sites</scene> in the ASP Structure (Ca1, Ca2 and Ca3). <scene name='82/829344/Ca1_et_ca2/4'>Ca1 and Ca2</scene> are situated in the N-terminal domain, and <scene name='82/829344/Ca3/1'>Ca3</scene> is situated in the C-terminal domain. It were assigned to ASP based on electron density, counter charges, and coordination. But in contrary to ''Kex2'', ASP contains no Ca2+ binding sites near its catalytic site. Those Ca2+ binding Site are important because ...

Sandbox Reserved 1091: Difference between revisions

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@@ Line 22: / Line 22: @@
 The '''structure of ASP''' is very similar to that of ''Kex2'' ([[1r64]]), but it has a unique extra-occluding region close to its active site within the subtilisin domains. This extra-occluding region is unique and it could serve as a useful target to make the development of new antisepsis drugs easier.
-The '''domain structure of ASP''' consists of the propeptide, the catalytic subtilisin-like domain, and the P-domain. The ASP molecule have two mean regions: an N-terminal region extending from Gly-3 to Pro-431 and forming the <scene name='82/829344/The_subtilisin_domain/1'>subtilisin domain</scene>, and a C-terminal region extending from Leu-432 to His-595 and forming the <scene name='82/829344/The_p-domain/2'>P-domain</scene>.
+The '''domain structure of ASP''' consists of the propeptide, the catalytic subtilisin-like domain, and the P-domain. The ASP molecule have two mean regions: an N-terminal region extending from Gly-3 to Pro-431 and forming the <scene name='82/829344/The_subtilisin_domain/2'>subtilisin domain</scene>, and a C-terminal region extending from Leu-432 to His-595 and forming the <scene name='82/829344/The_p-domain/2'>P-domain</scene>.
-Moreover, we can find three <scene name='82/829344/Calcium_binding_sites/2'>Ca2+ Binding Sites</scene> in the ASP Structure (Ca1, Ca2 and Ca3). <scene name='82/829344/Ca1_et_ca2/1'>Ca1 and Ca2</scene> are situated in the N-terminal domain, and <scene name='82/829344/Ca3/1'>Ca3</scene> is situated in the C-terminal domain. It were assigned to ASP based on electron density, counter charges, and coordination. But in contrary to ''Kex2'', ASP contains no Ca2+ binding sites near its catalytic site. Those Ca2+ binding Site are important because ...
+Moreover, we can find three <scene name='82/829344/Calcium_binding_sites/2'>Ca2+ Binding Sites</scene> in the ASP Structure (Ca1, Ca2 and Ca3). <scene name='82/829344/Ca1_et_ca2/4'>Ca1 and Ca2</scene> are situated in the N-terminal domain, and <scene name='82/829344/Ca3/1'>Ca3</scene> is situated in the C-terminal domain. It were assigned to ASP based on electron density, counter charges, and coordination. But in contrary to ''Kex2'', ASP contains no Ca2+ binding sites near its catalytic site. Those Ca2+ binding Site are important because ...