Sandbox Reserved 1094: Difference between revisions
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Depending on several conditions, it can dimerize to form tetramers. Each monomer is composed of a small domain localized in the amino terminal part which constitute the coenzyme binding domain and a larger domain in the carboxy terminal part which constitute the substrate binding domain. the complex has a substrate binding site that binds to G6P, and a catalytic coenzyme binding site that binds to NADP+ using the Rossman fold.<ref name="struc">PMID: 7881907</ref> | Depending on several conditions, it can dimerize to form tetramers. Each monomer is composed of a small domain localized in the amino terminal part which constitute the coenzyme binding domain and a larger domain in the carboxy terminal part which constitute the substrate binding domain. the complex has a substrate binding site that binds to G6P, and a catalytic coenzyme binding site that binds to NADP+ using the Rossman fold.<ref name="struc">PMID: 7881907</ref> | ||
''Coenzyme binding domain'' | *''Coenzyme binding domain'' | ||
The coenzyme binding domain binds the [[NAD]] or [[NADP]] which participes in the dehydrogenation of '''G6P'''. | The coenzyme binding domain binds the [[NAD]] or [[NADP]] which participes in the dehydrogenation of '''G6P'''. | ||
It is defined by a typical [https://scop.berkeley.edu/sunid=30074 β-α-β dinucleotide-binding fold] corresponding to a [https://en.wikipedia.org/wiki/Rossmann_fold Rossman fold]. | It is defined by a typical [https://scop.berkeley.edu/sunid=30074 β-α-β dinucleotide-binding fold] corresponding to a [https://en.wikipedia.org/wiki/Rossmann_fold Rossman fold]. | ||
