Sandbox Reserved 1095: Difference between revisions
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<StructureSection load='4zud' size='376' name='AT1R' caption='Human angiotensin receptor'> | <StructureSection load='4zud' size='376' name='AT1R' caption='Human angiotensin receptor'> | ||
== Functions == | == Functions == | ||
The AT1 receptors are playing an important role in the regulation of the renin-angiotensin-aldosterone system and therefore in the regulation of the cardiovascular physiology. It occupies a crucial place in the maintaining of blood pressure, electrolyte homeostasis, water balance, hormone secretion and renal functions. | The AT1 receptors are playing an important role in the regulation of [https://fr.wikipedia.org/wiki/Syst%C3%A8me_r%C3%A9nine-angiotensine-aldost%C3%A9rone the renin-angiotensin-aldosterone system] and therefore in the regulation of the cardiovascular physiology. It occupies a crucial place in the maintaining of blood pressure, electrolyte homeostasis, water balance, hormone secretion and renal functions. | ||
AT1 receptors are seven transmembrane-spanning G protein-coupled receptors. They interact with the angiotensin II, their ligand, and are therefore responsible for the triggering of intracellular signal transduction cascades mediating most functions of Angiotensin II, such as vasoconstriction, sympathetic nervous stimulation, increased aldosterone biosynthesis and renal functions. AT1 receptors are predominantly expressed in cardiovascular tissues including heart, endothelium, kidney, vascular smooth muscle cells as well as lungs, brain and adrenal cortex. | AT1 receptors are seven transmembrane-spanning G protein-coupled receptors. They interact with the angiotensin II, their ligand, and are therefore responsible for the triggering of intracellular signal transduction cascades mediating most functions of Angiotensin II, such as vasoconstriction, sympathetic nervous stimulation, increased aldosterone biosynthesis and renal functions. AT1 receptors are predominantly expressed in cardiovascular tissues including heart, endothelium, kidney, vascular smooth muscle cells as well as lungs, brain and adrenal cortex. | ||
