Sandbox Reserved 1095: Difference between revisions

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=== Recent studies ===

Finally, around 2015, researchers have found the crystal structure of the receptor in complex with its antagonist [https://pubchem.ncbi.nlm.nih.gov/compound/ZD-7155-hydrochloride ZD7155] and with an inverse agonist [https://en.wikipedia.org/wiki/Olmesartan olmesartan]<ref ~~name="Zhang2015"~~> ~~[https~~://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705918/ Zhang H, Unal H, Desnoyer R, et al. Structural Basis for Ligand Recognition and Functional Selectivity at Angiotensin Receptor. J Biol Chem. 2015;290(49):29127–29139. doi:10.1074/jbc.M115.689000] </ref>. [https://en.wikipedia.org/wiki/X-ray_crystallography X-ray cryogenic-crystallography] has been used. They have found similar conformation of the receptor when it is linked to the antagonist or to the inverse agonist. They have also found conserved molecular recognition modes. To complete this, they have performed mutagenesis experiments and managed to identify several residues in interaction with the ligand.

Finally, around 2015, researchers have found the crystal structure of the receptor in complex with its antagonist [https://pubchem.ncbi.nlm.nih.gov/compound/ZD-7155-hydrochloride ZD7155] and with an inverse agonist [https://en.wikipedia.org/wiki/Olmesartan olmesartan]<ref> PMID: 26420482 </ref>. [https://en.wikipedia.org/wiki/X-ray_crystallography X-ray cryogenic-crystallography] has been used. They have found similar conformation of the receptor when it is linked to the antagonist or to the inverse agonist. They have also found conserved molecular recognition modes. To complete this, they have performed mutagenesis experiments and managed to identify several residues in interaction with the ligand.

The structure of this protein have also been solved in 2017 using an other method called serial femtosecond crystallography, corresponding to the structure [http://proteopedia.org/wiki/index.php/4yay 4YAY] <ref name="Zhang2017">[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427029/ Zhang H, Unal H, Gati C, et al. Structure of the Angiotensin receptor revealed by serial femtosecond crystallography. Cell. 2015;161(4):833–844. doi:10.1016/j.cell.2015.04.011]</ref>.

Sandbox Reserved 1095: Difference between revisions

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@@ Line 22: / Line 22: @@
 === Recent studies ===
-Finally, around 2015, researchers have found the crystal structure of the receptor in complex with its antagonist [https://pubchem.ncbi.nlm.nih.gov/compound/ZD-7155-hydrochloride ZD7155] and with an inverse agonist [https://en.wikipedia.org/wiki/Olmesartan olmesartan]<ref name="Zhang2015"> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705918/ Zhang H, Unal H, Desnoyer R, et al. Structural Basis for Ligand Recognition and Functional Selectivity at Angiotensin Receptor. J Biol Chem. 2015;290(49):29127–29139. doi:10.1074/jbc.M115.689000] </ref>. [https://en.wikipedia.org/wiki/X-ray_crystallography X-ray cryogenic-crystallography] has been used. They have found similar conformation of the receptor when it is linked to the antagonist or to the inverse agonist. They have also found conserved molecular recognition modes. To complete this, they have performed mutagenesis experiments and managed to identify several residues in interaction with the ligand.
+Finally, around 2015, researchers have found the crystal structure of the receptor in complex with its antagonist [https://pubchem.ncbi.nlm.nih.gov/compound/ZD-7155-hydrochloride ZD7155] and with an inverse agonist [https://en.wikipedia.org/wiki/Olmesartan olmesartan]<ref> PMID: 26420482 </ref>. [https://en.wikipedia.org/wiki/X-ray_crystallography X-ray cryogenic-crystallography] has been used. They have found similar conformation of the receptor when it is linked to the antagonist or to the inverse agonist. They have also found conserved molecular recognition modes. To complete this, they have performed mutagenesis experiments and managed to identify several residues in interaction with the ligand.
 The structure of this protein have also been solved in 2017 using an other method called serial femtosecond crystallography, corresponding to the structure [http://proteopedia.org/wiki/index.php/4yay 4YAY] <ref name="Zhang2017">[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427029/ Zhang H, Unal H, Gati C, et al. Structure of the Angiotensin receptor revealed by serial femtosecond crystallography. Cell. 2015;161(4):833–844. doi:10.1016/j.cell.2015.04.011]</ref>.