Sandbox Reserved 1102: Difference between revisions

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ATP hydrolysis is the most basic event to the function of this helicase; however, the other dynamic mechanisms remain largely unknown, impeding the further understanding of the function of Zika helicase.  
ATP hydrolysis is the most basic event to the function of this helicase; however, the other dynamic mechanisms remain largely unknown, impeding the further understanding of the function of Zika helicase.  
<ref> Mechanism of ATP hydrolysis by the Zika virus helicase, The Faseb journal, 27 sep 2018, X. Yang and H. Yang conceived of and designed the experiments; X. Yang, H. Tian, H. Chi, Z. Mu, and T. Zhang performed the experiments; C. Chen, K. Yang, Q. Zhao, Z. Wang, X. Ji, and H. Yang analyzed the data; and X. Yang, C. Chen, X. Liu, and H. Yang wrote the paper.; https://www.fasebj.org/doi/10.1096/fj.201701140R </ref>
<ref> Hongliang Tian, Xiaoyun Ji, Xiaoyun Yang, Zhongxin Zhang, Zuokun Lu, Kailin Yang, Cheng Chen, Qi Zhao, Heng Chi, Zhongyu Mu, Wei Xie, Zefang Wang, Huiqiang Lou, Haitao Yang and Zihe Rao. Structural basis of Zika virus helicase in recognizing its substrates[J]. Protein&Cell, 2016, 7(8): 562-570. doi: 10.1007/s13238-016-0293-2 http://www.protein-cell.org/en/article/doi/10.1007/s13238-016-0293-2 </ref>


== Structural highlights ==
== Structural highlights ==
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== Disease ==
== Disease ==


[https://en.wikipedia.org/wiki/Zika_virus#Pregnancy Zika virus (ZIKV)] <ref name ="Xiaoyun Yang et al">,  "Xiaoyun Yang, Cheng Chen, Hongliang Tian, Heng Chi, Zhongyu Mu, Tianqing Zhang, Kailin Yang,  Qi Zhao,  Xiaohua Liu,  Zefang Wang, Xiaoyun Ji, and Haitao Yang, Mechanism of ATP hydrolysis by the Zika virus helicase, FASEBjournal, pp 5250-5257„https://www.fasebj.org/doi/10.1096/fj.201701140R </ref> is a member of the [https://en.wikipedia.org/wiki/Flavivirus Flavivirus ] genus, of the virus family [https://en.wikipedia.org/wiki/Flaviviridae Flaviviridae.]
[https://en.wikipedia.org/wiki/Zika_virus#Pregnancy Zika virus (ZIKV)] <ref name ="Xiaoyun Yang et al">,  "Xiaoyun Yang, Cheng Chen, Hongliang Tian, Heng Chi, Zhongyu Mu, Tianqing Zhang, Kailin Yang,  Qi Zhao,  Xiaohua Liu,  Zefang Wang, Xiaoyun Ji, and Haitao Yang, Mechanism of ATP hydrolysis by the Zika virus helicase, FASEBjournal, pp 5250-5257„ </ref> is a member of the [https://en.wikipedia.org/wiki/Flavivirus Flavivirus ] genus, of the virus family [https://en.wikipedia.org/wiki/Flaviviridae Flaviviridae.]
The Flavivirus genus comprises the [https://en.wikipedia.org/wiki/Dengue_virus dengue virus ] (DENV), [https://en.wikipedia.org/wiki/Yellow_fever#Cause yellow fever virus], [https://en.wikipedia.org/wiki/West_Nile_virus West Nile virus], [https://en.wikipedia.org/wiki/Japanese_encephalitis#Virology Japanese encephalitis virus], and [https://en.wikipedia.org/wiki/Tick-borne_encephalitis_virus tick-borne encephalitis virus]. It is transmitted by daytime-active [https://en.wikipedia.org/wiki/Aedes Aedes] mosquitoes.  
The Flavivirus genus comprises the [https://en.wikipedia.org/wiki/Dengue_virus dengue virus ] (DENV), [https://en.wikipedia.org/wiki/Yellow_fever#Cause yellow fever virus], [https://en.wikipedia.org/wiki/West_Nile_virus West Nile virus], [https://en.wikipedia.org/wiki/Japanese_encephalitis#Virology Japanese encephalitis virus], and [https://en.wikipedia.org/wiki/Tick-borne_encephalitis_virus tick-borne encephalitis virus]. It is transmitted by daytime-active [https://en.wikipedia.org/wiki/Aedes Aedes] mosquitoes.  


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