Sandbox Reserved 1094: Difference between revisions
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<font color='grey'>External resource</font> : click on [https://www.rcsb.org/pdb/explore/remediatedSequence.do?structureId=1DPG] to see the graphical representation on the RCSB website. | <font color='grey'>External resource</font> : click on [https://www.rcsb.org/pdb/explore/remediatedSequence.do?structureId=1DPG] to see the graphical representation on the RCSB website. | ||
[[Image:Pathology of G6PD deficiency.png| | [[Image:Pathology of G6PD deficiency.png|200px|upright|thumb| G6PD pathway. Obtained from https://en.wikipedia.org/wiki/Glucose-6-phosphate_dehydrogenase]] | ||
== Catalytic activity == | == Catalytic activity == | ||
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KM=114 µM for '''G6PD''' (with NADP), KM=69 µM for '''G6PD''' (with NAD), | KM=114 µM for '''G6PD''' (with NADP), KM=69 µM for '''G6PD''' (with NAD), | ||
KM=8.0 µM for [ | KM=8.0 µM for [https://en.wikipedia.org/wiki/Nicotinamide_adenine_dinucleotide_phosphate NADP], KM=160 µM for [[NAD]]. | ||
Its regulation depends on the concentration of substrate and coenzyme, rate limiting step in pentose phosphate pathway<ref>PMID: 12033926</ref>. | Its regulation depends on the concentration of substrate and coenzyme, rate limiting step in pentose phosphate pathway<ref>PMID: 12033926</ref>. | ||
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== Evolutionary conservation == | == Evolutionary conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | |||
The different structures conserved evolutionary can be observed according to the scale following. | The different structures conserved evolutionary can be observed according to the scale following. | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
