Sandbox Reserved 1093: Difference between revisions
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On the N-term fixation site, LRRTM2 binds specifically to Neurexin1 α and β. The affinity of the binding depends on the splicing of the insert SS4 of both neurexins. This binding plays a critical role in the formation of excitatory synapses as it briges the synaptic cleft. Without Neurexin1, LRRTM2 can't act on presynaptic differentiation leading to a reduction in the amount of excitatory synapses. In addition, the presynaptic receptors Neurexin 1 α and β are known to be receptors for Neurologine 1, a protein similar to LRRTM2. Neurologine 1 also regulates the formation of excitatory synapses. | On the N-term fixation site, LRRTM2 binds specifically to Neurexin1 α and β. The affinity of the binding depends on the splicing of the insert SS4 of both neurexins. This binding plays a critical role in the formation of excitatory synapses as it briges the synaptic cleft. Without Neurexin1, LRRTM2 can't act on presynaptic differentiation leading to a reduction in the amount of excitatory synapses. In addition, the presynaptic receptors Neurexin 1 α and β are known to be receptors for Neurologine 1, a protein similar to LRRTM2. Neurologine 1 also regulates the formation of excitatory synapses. | ||
[[Image:LRRTM2functions.png|1100px|left]] | |||
== Related Structures == | == Related Structures == | ||
