Sandbox Reserved 1093: Difference between revisions
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'''Interaction with intracellular proteins''' | '''Interaction with intracellular proteins''' | ||
It has been shown that the binding of LRRTM2 with PSD-95 [http://proteopedia.org/wiki/index.php/1tq3] on the C-term fixation site was responsible for the regulation of AMPA receptor [http://proteopedia.org/wiki/index.php/AMPA] expression. The AMPA receptors ( AMPARs) are transmembrane receptors located on the postsynaptic membrane that interact with glutamates (neurotransmittters). So, the expression of LRRTM2 in the neurons of the hippocampus have a direct link with the density of excitatory synapses. The greater the quantity of LRRTM2, the greater the density of excitatory synapses. Thus, LRRTM2 has a direct influence on the glutamatergic synaptic transmission strength. | It has been shown that the binding of LRRTM2 with PSD-95 [http://proteopedia.org/wiki/index.php/1tq3] on the C-term fixation site was responsible for the regulation of <scene name='82/829346/Ampa/1'>AMPA receptor</scene> [http://proteopedia.org/wiki/index.php/AMPA] expression. The AMPA receptors ( AMPARs) are transmembrane receptors located on the postsynaptic membrane that interact with glutamates (neurotransmittters). So, the expression of LRRTM2 in the neurons of the hippocampus have a direct link with the density of excitatory synapses. The greater the quantity of LRRTM2, the greater the density of excitatory synapses. Thus, LRRTM2 has a direct influence on the glutamatergic synaptic transmission strength. | ||
It has also been noted that the repression of LRRTM2 induced a decrease in the density of PSD-95. Thus, LRRTM2 recruits PSD-95 at postsynaptic density and then binds to PSD-95 via the ECFV cytoplasmic motif. The interaction of PSD-95 with glutamate receptors, located at the postsynaptic membrane, as well as with other synaptic synaptic proteins. | It has also been noted that the repression of LRRTM2 induced a decrease in the density of PSD-95. Thus, LRRTM2 recruits PSD-95 at postsynaptic density and then binds to PSD-95 via the ECFV cytoplasmic motif. The interaction of PSD-95 with glutamate receptors, located at the postsynaptic membrane, as well as with other synaptic synaptic proteins. | ||
By the interaction with important postsynaptic components, LRRTM2 turns out to be crucial in the regulation of the postsynaptic fonctions and plasticity. | By the interaction with important postsynaptic components, LRRTM2 turns out to be crucial in the regulation of the postsynaptic fonctions and plasticity. | ||
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'''Interaction with extracellular proteins''' | '''Interaction with extracellular proteins''' | ||
On the N-term fixation site, LRRTM2 binds specifically to Neurexin1 α and β [http://proteopedia.org/wiki/index.php/Neurexin]. The affinity of the binding depends on the splicing of the insert SS4 of both neurexins. This binding plays a critical role in the formation of excitatory synapses as it briges the synaptic cleft. Without Neurexin1, LRRTM2 can't act on presynaptic differentiation leading to a reduction in the amount of excitatory synapses. In addition, the presynaptic receptors Neurexin 1 α and β are known to be receptors for | On the N-term fixation site, LRRTM2 binds specifically to Neurexin1 <scene name='82/829346/Neurexin_1_alpha/1'>α</scene> and <scene name='82/829346/Beta-neurexin_1/2'>β</scene> [http://proteopedia.org/wiki/index.php/Neurexin]. The affinity of the binding depends on the splicing of the insert SS4 of both neurexins. This binding plays a critical role in the formation of excitatory synapses as it briges the synaptic cleft. Without Neurexin1, LRRTM2 can't act on presynaptic differentiation leading to a reduction in the amount of excitatory synapses. In addition, the presynaptic receptors Neurexin 1 α and β are known to be receptors for <scene name='82/829346/Neurologin-neurexin/1'>Neurologin 1</scene> [http://proteopedia.org/wiki/index.php/3vkf], a protein similar to LRRTM2. Neurologin 1 also regulates the formation of excitatory synapses. | ||
[[Image:LRRTM2functions.png|1100px|left]] | [[Image:LRRTM2functions.png|1100px|left]] | ||
