Sandbox Reserved 1093: Difference between revisions
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'''LRRTMs Family
''' | '''LRRTMs Family
''' | ||
All four members of the human LRRTM family are highly similar in their LRR domains with >55% sequence identity. But only LRRTM1 and LRRTM2 have been extensively studied in the context of the interaction with | All four members of the human LRRTM family are highly similar in their LRR domains with >55% sequence identity. But only LRRTM1 and LRRTM2 have been extensively studied in the context of the interaction with neurexins[http://proteopedia.org/wiki/index.php/Neurexin]. This is due to the fact that some critical residues for binding with <scene name='82/829346/Beta-neurexin_1/2'>Nrxn1β</scene> have been replaced in LRRTM3 and LRRTM4, such as <scene name='82/829346/Glu_348/1'>Glu348</scene>, <scene name='82/829346/Asp_352/1'>Asp352</scene>, and <scene name='82/829346/Phe_357/2'>Phe357</scene>. | ||
The replacement of Glu348 by Val in LRRTM3 is likely to prevent of the interaction between Ca2+ and Nrxn1β. It is possible that other specific residue(s) of LRRTM3/4 may also prevent the binding. | The replacement of Glu348 by Val in LRRTM3 is likely to prevent of the interaction between Ca2+ and Nrxn1β. It is possible that other specific residue(s) of LRRTM3/4 may also prevent the binding. | ||
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Neuroligins (NLs) | Neuroligins (NLs)[http://proteopedia.org/wiki/index.php/3vkf] | ||
LRRTM2 bind to Neurexins 1, 2 and 3 ︎and ︎a variant region at splice site 4 in the LNS. As the variant region lacking a 30 amino acid insert (-S4), LRRTM2 cannot induce presynaptic differentiation in neurons. On the contrary, <scene name='82/829346/Neurologin-neurexin/1'>Neuroligin1</scene> binds to Neurexins 1, 2, and 3, has a higher affinity with Neurexin 1 (-S4) than with Neurexin 1 (+S4) | |||
LRRTM2 bind to Neurexins 1, 2 and 3 ︎and ︎a variant region at splice site 4 in the LNS. As the variant region lacking a 30 amino acid insert (-S4), LRRTM2 cannot induce presynaptic differentiation in neurons. On the contrary, Neuroligin1 binds to Neurexins 1, 2, and 3, has a higher affinity with Neurexin 1 (-S4) than with Neurexin 1 (+S4) | |||
