Sandbox Reserved 1093: Difference between revisions

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Neuroligins (NLs)[http://proteopedia.org/wiki/index.php/3vkf]

LRRTM2 bind to Neurexins 1, 2 and 3 ︎and ︎a variant region at splice site 4 in the LNS. As the variant region lacking a 30 amino acid insert (-S4), LRRTM2 cannot induce presynaptic differentiation in neurons. On the contrary, <scene name='82/829346/Neurologin-neurexin/1'>Neuroligin1</scene> binds to Neurexins 1, 2, and 3, has a higher affinity with Neurexin 1 (-S4) than with Neurexin 1 (+S4)

LRRTM2 bind to Neurexins 1, 2 and 3 ︎and ︎a variant region at splice site 4 in the LNS. As the variant region lacking a 30 amino acid insert (-S4), LRRTM2 cannot induce presynaptic differentiation in neurons. On the contrary, <scene name='82/829346/Neurologin-neurexin/1'>Neuroligin1</scene> binds to Neurexins 1, 2, and 3, has a higher affinity with Neurexin 1 (-S4) than with Neurexin 1 (+S4).

Neuroligins have the same function as LRRTMs. Those proteins works in a summative way to enhance the recruitment of presynaptic proteins. Neuroligins can compensate for reduced LRRTMs functions.

== Disease ==

~~A large~~ number of ~~researches shows~~ that ~~LRRTM2 is related~~ to ~~bipolar disorder. In~~ the ~~same time,~~ LRRTM2 is also ~~associated with other neuropsychiatric disorders such as schizophrenia~~ and ~~autism spectrum disorders~~.

Autism Spectrum Disorders (ASDs) is a broad group of various autism disorders such as Asperger, Rett and others development disorders. It is also associated to schizophrenia and Tourette Syndrome. An important number of proteins are implicated in those diseases and only a few are actually been proven to be linked to those disorders. Both neurexins and LRR proteins are good candidates. It have been shown that mutation in Nrxn1 can lead to modification of the LNS fixation site (part that binds to LRRTM2) resulting in autism. It was also demonstrated that mutations in LRR lead to hereditary lateral temporal epilepsy and Parkinson.

A deletion (240 kb) at 5q31 chromosomal region containing LRRTM2 ~~and CTNNA1~~ has been shown to be related to intellectual disability and developmental delay.

A deletion (240 kb) at 5q31 chromosomal region containing LRRTM2 has been shown to be related to intellectual disability and developmental delay.

Some studies also show that LRRTM2 is also related to bipolar disorder.

== References ==

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https://onlinelibrary.wiley.com/doi/pdf/10.1111/jnc.13159

https://www.rcsb.org/structure/5Z8X

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066302/pdf/nihms258120.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913944/pdf/2040-2392-1-7.pdf

https://espace.library.uq.edu.au/view/UQ:313747

Sandbox Reserved 1093: Difference between revisions

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@@ Line 63: / Line 63: @@
 Neuroligins (NLs)[http://proteopedia.org/wiki/index.php/3vkf]
-LRRTM2 bind to Neurexins 1, 2 and 3 ︎and ︎a variant region at splice site 4 in the LNS. As the variant region lacking a 30 amino acid insert (-S4), LRRTM2 cannot induce presynaptic differentiation in neurons. On the contrary, <scene name='82/829346/Neurologin-neurexin/1'>Neuroligin1</scene> binds to Neurexins 1, 2, and 3, has a higher affinity with Neurexin 1 (-S4) than with Neurexin 1 (+S4)
+LRRTM2 bind to Neurexins 1, 2 and 3 ︎and ︎a variant region at splice site 4 in the LNS. As the variant region lacking a 30 amino acid insert (-S4), LRRTM2 cannot induce presynaptic differentiation in neurons. On the contrary, <scene name='82/829346/Neurologin-neurexin/1'>Neuroligin1</scene> binds to Neurexins 1, 2, and 3, has a higher affinity with Neurexin 1 (-S4) than with Neurexin 1 (+S4).
+Neuroligins have the same function as LRRTMs. Those proteins works in a summative way to enhance the recruitment of presynaptic proteins. Neuroligins can compensate for reduced LRRTMs functions.
 == Disease ==
-A large number of researches shows that LRRTM2 is related to bipolar disorder. In the same time, LRRTM2 is also associated with other neuropsychiatric disorders such as schizophrenia and autism spectrum disorders.
+Autism Spectrum Disorders (ASDs) is a broad group of various autism disorders such as Asperger, Rett and others development disorders. It is also associated to schizophrenia and Tourette Syndrome. An important number of proteins are implicated in those diseases and only a few are actually been proven to be linked to those disorders. Both neurexins and LRR proteins are good candidates. It have been shown that mutation in Nrxn1 can lead to modification of the LNS fixation site (part that binds to LRRTM2) resulting in autism. It was also demonstrated that mutations in LRR lead to hereditary lateral temporal epilepsy and Parkinson.
-A deletion (240 kb) at 5q31 chromosomal region containing LRRTM2 and CTNNA1 has been shown to be related to intellectual disability and developmental delay.
+A deletion (240 kb) at 5q31 chromosomal region containing LRRTM2 has been shown to be related to intellectual disability and developmental delay.
+Some studies also show that LRRTM2 is also related to bipolar disorder.
 == References ==
@@ Line 84: / Line 89: @@
 https://onlinelibrary.wiley.com/doi/pdf/10.1111/jnc.13159
 https://www.rcsb.org/structure/5Z8X
+https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066302/pdf/nihms258120.pdf
+https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913944/pdf/2040-2392-1-7.pdf
+https://espace.library.uq.edu.au/view/UQ:313747