Sandbox Reserved 1093: Difference between revisions

LRRTM2 bind to Neurexins 1, 2 and 3 ︎and ︎a variant region at splice site 4 in the LNS. As the variant region lacking a 30 amino acid insert (-S4), LRRTM2 cannot induce presynaptic differentiation in neurons. On the contrary, <scene name='82/829346/Neurologin-neurexin/1'>Neuroligin1</scene> binds to Neurexins 1, 2, and 3, has a higher affinity with Neurexin 1 (-S4) than with Neurexin 1 (+S4). As both Neuroligins and LRRTMs bind to Neurexins, Neuroligins can compensate for reduced LRRTMs functions. Those proteins works in a summative way to enhance the recruitment of presynaptic protein.