Sandbox Reserved 1105: Difference between revisions

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Identified on 1942, Human transthyretin (TTR) ([[1dvq]]) is a transport protein encoded by the TTR gene, located on chromosome 18 <ref> Wallace MR, Naylor SL, Kluve-Beckerman B, Long GL, McDonald L, Shows TB, Benson MD, Localization of the human prealbumin gene to chromosome 18, Biochem Biophys Res Commun, 1985;129:753–758 doi:https://doi.org/10.1016/0006-291X(85)91956-4 </ref>. It is mainly present in the plasma and synthetized by the liver, but also in the cerebrospinal fluid produced by the choroid plexus of the brain, and in retinal pigment epithelium. This protein was originally called prealbumin as it runs faster than albumin ([[1bm0]]) during SDS-PAGE <ref> Seibert FB, Nelson JW. Electrophoretic study of the blood protein response in tuberculosis. J Biol Chem 1942; 143: 29–38. </ref>. After discovering its binding and transport ability to thyroxine (T4), it was given the name of “thyroxine-binding prealbumin” (TBPA). Indeed, its role is crucial as it allows essential thyroid hormones, implied in cell differenciation, growth and metabolic regulation<ref> Wikipedia contributors. "Thyroid hormones." Wikipedia, The Free Encyclopedia. (accessed on Jan. 16 2020)</ref>, to pass through the bloodstream. Finally, its actual name refers to an additional carrier function: '''trans'''ports '''thyr'''oxine and '''retin'''ol (one form of vitamin A). Recently, it has been found that TTR also has a role in proteolysis, and in the nervous system, implicated axonal growth, neurogenesis, and nerve regeneration<ref name= "Vieira">Vieira M, Saraiva MJ, Transthyretin: a multifaceted protein, Biomol Concepts, 2014;5:45–54 doi: https://doi.org/10.1515/bmc-2013-0038</ref>.

Identified on 1942, Human transthyretin (TTR) ([[1dvq]]) is a transport protein encoded by the TTR gene, located on chromosome 18 <ref> Wallace MR, Naylor SL, Kluve-Beckerman B, Long GL, McDonald L, Shows TB, Benson MD, Localization of the human prealbumin gene to chromosome 18, Biochem Biophys Res Commun, 1985;129:753–758 doi:https://doi.org/10.1016/0006-291X(85)91956-4 </ref>. It is mainly present in the plasma and synthetized by the liver, but also in the cerebrospinal fluid produced by the choroid plexus of the brain, and in retinal pigment epithelium. This protein was originally called prealbumin as it runs faster than albumin ([[1bm0]]) during SDS-PAGE <ref> Seibert FB, Nelson JW. Electrophoretic study of the blood protein response in tuberculosis. J Biol Chem 1942; 143: 29–38. </ref>. After discovering its binding and transport ability to thyroxine (T4), it was given the name of “thyroxine-binding prealbumin” (TBPA). Indeed, its role is crucial as it allows essential thyroid hormones, implied in cell differenciation, growth and metabolic regulation<ref> Wikipedia contributors. "Thyroid hormones." Wikipedia, The Free Encyclopedia. [https://en.wikipedia.org/wiki/Thyroid_hormones] (accessed on Jan. 16 2020)</ref>, to pass through the bloodstream. Finally, its actual name refers to an additional carrier function: '''trans'''ports '''thyr'''oxine and '''retin'''ol (one form of vitamin A). Recently, it has been found that TTR also has a role in proteolysis, and in the nervous system, implicated axonal growth, neurogenesis, and nerve regeneration<ref name= "Vieira">Vieira M, Saraiva MJ, Transthyretin: a multifaceted protein, Biomol Concepts, 2014;5:45–54 doi: https://doi.org/10.1515/bmc-2013-0038</ref>.

Sandbox Reserved 1105: Difference between revisions

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Revision as of 22:38, 16 January 2020 view source Korelly Srivongsana (talk \| contribs) 28 edits No edit summary ← Older edit		Latest revision as of 22:58, 16 January 2020 view source Korelly Srivongsana (talk \| contribs) 28 edits No edit summary
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	Identified on 1942, Human transthyretin (TTR) ([[1dvq]]) is a transport protein encoded by the TTR gene, located on chromosome 18 <ref> Wallace MR, Naylor SL, Kluve-Beckerman B, Long GL, McDonald L, Shows TB, Benson MD, Localization of the human prealbumin gene to chromosome 18, Biochem Biophys Res Commun, 1985;129:753–758 doi:https://doi.org/10.1016/0006-291X(85)91956-4 </ref>. It is mainly present in the plasma and synthetized by the liver, but also in the cerebrospinal fluid produced by the choroid plexus of the brain, and in retinal pigment epithelium. This protein was originally called prealbumin as it runs faster than albumin ([[1bm0]]) during SDS-PAGE <ref> Seibert FB, Nelson JW. Electrophoretic study of the blood protein response in tuberculosis. J Biol Chem 1942; 143: 29–38. </ref>. After discovering its binding and transport ability to thyroxine (T4), it was given the name of “thyroxine-binding prealbumin” (TBPA). Indeed, its role is crucial as it allows essential thyroid hormones, implied in cell differenciation, growth and metabolic regulation<ref> Wikipedia contributors. "Thyroid hormones." Wikipedia, The Free Encyclopedia. (accessed on Jan. 16 2020)</ref>, to pass through the bloodstream. Finally, its actual name refers to an additional carrier function: '''trans'''ports '''thyr'''oxine and '''retin'''ol (one form of vitamin A). Recently, it has been found that TTR also has a role in proteolysis, and in the nervous system, implicated axonal growth, neurogenesis, and nerve regeneration<ref name= "Vieira">Vieira M, Saraiva MJ, Transthyretin: a multifaceted protein, Biomol Concepts, 2014;5:45–54 doi: https://doi.org/10.1515/bmc-2013-0038</ref>.		Identified on 1942, Human transthyretin (TTR) ([[1dvq]]) is a transport protein encoded by the TTR gene, located on chromosome 18 <ref> Wallace MR, Naylor SL, Kluve-Beckerman B, Long GL, McDonald L, Shows TB, Benson MD, Localization of the human prealbumin gene to chromosome 18, Biochem Biophys Res Commun, 1985;129:753–758 doi:https://doi.org/10.1016/0006-291X(85)91956-4 </ref>. It is mainly present in the plasma and synthetized by the liver, but also in the cerebrospinal fluid produced by the choroid plexus of the brain, and in retinal pigment epithelium. This protein was originally called prealbumin as it runs faster than albumin ([[1bm0]]) during SDS-PAGE <ref> Seibert FB, Nelson JW. Electrophoretic study of the blood protein response in tuberculosis. J Biol Chem 1942; 143: 29–38. </ref>. After discovering its binding and transport ability to thyroxine (T4), it was given the name of “thyroxine-binding prealbumin” (TBPA). Indeed, its role is crucial as it allows essential thyroid hormones, implied in cell differenciation, growth and metabolic regulation<ref> Wikipedia contributors. "Thyroid hormones." Wikipedia, The Free Encyclopedia. [https://en.wikipedia.org/wiki/Thyroid_hormones] (accessed on Jan. 16 2020)</ref>, to pass through the bloodstream. Finally, its actual name refers to an additional carrier function: '''trans'''ports '''thyr'''oxine and '''retin'''ol (one form of vitamin A). Recently, it has been found that TTR also has a role in proteolysis, and in the nervous system, implicated axonal growth, neurogenesis, and nerve regeneration<ref name= "Vieira">Vieira M, Saraiva MJ, Transthyretin: a multifaceted protein, Biomol Concepts, 2014;5:45–54 doi: https://doi.org/10.1515/bmc-2013-0038</ref>.