Sandbox Reserved 1109: Difference between revisions
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== Disease == | == Disease == | ||
One of the main characteristics of Neurodegenerative disorders is the loss of the protective capacity surrounding the neurons or the gain of the toxic proteins. The mechanism by which the neuronal damage occurs is due to specific mutations, or other alterations of the synaptic proteins. Recently, two main hypotheses have been developed surrounding Parkinson's disease research. Firstly, the missense mutation of the α-synuclein gene is a rare genetic disorder that | One of the main characteristics of Neurodegenerative disorders is the loss of the protective capacity surrounding the neurons or the gain of the toxic proteins. The mechanism by which the neuronal damage occurs is due to specific mutations, or other alterations of the synaptic proteins. Recently, two main hypotheses have been developed surrounding Parkinson's disease research. Firstly, the missense mutation of the α-synuclein gene is a rare genetic disorder that causes Parkinson's disease. Secondly, the α-synuclein protein is the main component of Lewy bodies and Lewy neurites which are defining pathological characteristics of all Parkinson's disease cases. <ref>https://doi.org/10.1038/35081564<ref> Parkinson's disease is characterized by the accumulation of Lewy bodies in the substantia nigra, where Lewy bodies contain a build-up of α-synuclein found within the cells that contribute to the disease <ref>PMID: 9546347<ref> | ||
== Relevance == | == Relevance == | ||
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https://doi.org/10.1038/35081564 | https://doi.org/10.1038/35081564 | ||
<references/> | <references/> | ||
<ref>PMID: 9546347<ref> | |||
