1abq: Difference between revisions

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[[Image:1abq.jpg|left|200px]]
{{Seed}}
[[Image:1abq.png|left|200px]]


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{{STRUCTURE_1abq|  PDB=1abq  |  SCENE=  }}  
{{STRUCTURE_1abq|  PDB=1abq  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF THE UNLIGANDED ABL TYROSINE KINASE SH3 DOMAIN'''
===CRYSTAL STRUCTURE OF THE UNLIGANDED ABL TYROSINE KINASE SH3 DOMAIN===




==Overview==
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Src-homology 3 (SH3) domains bind to proline-rich motifs in target proteins. We have determined high-resolution crystal structures of the complexes between the SH3 domains of Abl and Fyn tyrosine kinases, and two ten-residue proline-rich peptides derived from the SH3-binding proteins 3BP-1 and 3BP-2. The X-ray data show that the basic mode of binding of both proline-rich peptides is the same. Peptides are bound over their entire length and interact with three major sites on the SH3 molecules by both hydrogen-bonding and van der Waals contacts. Residues 4-10 of the peptide adopt the conformation of a left-handed polyproline helix type II. Binding of the proline at position 2 requires a kink at the non-proline position 3.
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{{ABSTRACT_PUBMED_7664083}}


==About this Structure==
==About this Structure==
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[[Category: Proto-oncogene]]
[[Category: Proto-oncogene]]
[[Category: Sh3 domain]]
[[Category: Sh3 domain]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:04:46 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:32:29 2008''

Revision as of 13:32, 30 June 2008

File:1abq.png

Template:STRUCTURE 1abq

CRYSTAL STRUCTURE OF THE UNLIGANDED ABL TYROSINE KINASE SH3 DOMAIN

Template:ABSTRACT PUBMED 7664083

About this Structure

1ABQ is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides., Musacchio A, Saraste M, Wilmanns M, Nat Struct Biol. 1994 Aug;1(8):546-51. PMID:7664083

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