Sandbox Reserved 1099: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 68: | Line 68: | ||
The gastric cancer is characterized by an overexpression of long non coding RNAs ([https://en.wikipedia.org/wiki/Long_non-coding_RNA_ lncRNA]) of stomach cancer associated transcript 3 (shortened as STCAT3). These RNAs, under the RNA form, run some functions of genes regulation such as gene expressions, control of the cell cycle, ect… Not only Dermicidin has been identified as the binding protein of lncRNA STCAT3, but also the Dermicidin expression has been shown stronger in the case of gastric cancer cells. So in the cancer cells the DCD can be found more abundant than in non-cancer cells. It can be used in the researches on the gastric cancer, hence to save lives.<ref> Zhang, J., Ding, W., Kuai, X., Ji, Y., Zhu, Z., Mao, Z., Wang, Z., 2018. Dermcidin as a novel binding protein of lncRNA STCAT3 and its effect on prognosis in gastric cancer. Oncol Rep. https://doi.org/10.3892/or.2018.6673 </ref> | The gastric cancer is characterized by an overexpression of long non coding RNAs ([https://en.wikipedia.org/wiki/Long_non-coding_RNA_ lncRNA]) of stomach cancer associated transcript 3 (shortened as STCAT3). These RNAs, under the RNA form, run some functions of genes regulation such as gene expressions, control of the cell cycle, ect… Not only Dermicidin has been identified as the binding protein of lncRNA STCAT3, but also the Dermicidin expression has been shown stronger in the case of gastric cancer cells. So in the cancer cells the DCD can be found more abundant than in non-cancer cells. It can be used in the researches on the gastric cancer, hence to save lives.<ref> Zhang, J., Ding, W., Kuai, X., Ji, Y., Zhu, Z., Mao, Z., Wang, Z., 2018. Dermcidin as a novel binding protein of lncRNA STCAT3 and its effect on prognosis in gastric cancer. Oncol Rep. https://doi.org/10.3892/or.2018.6673 </ref> | ||
Often times, dermcidin is in the discussion to function as a general biomarker for the above mentioned diseases but also being a potential target for anticancer drugs such as [https://www.biotrend-usa.com/other-products-186/seriniquinone-22200-69-7-566000900.html_ seriniquinone].<ref name="trzoss"/> The anticancer effect could derive from direct interaction or from protein complexes linked via disulfide bonds to DCD, which was already shown for [http://proteopedia.org/wiki/index.php/Hsp70_ Hsp70]. In the survival-promoting peptide area of dermcidin, GNPCH is considered to be an ATP-dependent binding-site for Hsp70.<ref> Stocki, P., Wang, X.N., Morris, N.J., Dickinson, A.M., 2011. HSP70 Natively and Specifically Associates with an N-terminal Dermcidin-derived Peptide That Contains an HLA-A*03 Antigenic Epitope. J. Biol. Chem. 286, 12803–12811. https://doi.org/10.1074/jbc.M110.179630 </ref> | Often times, dermcidin is in the discussion to function as a general '''biomarker''' for the above mentioned diseases but also being a potential '''target for anticancer drugs''' such as [https://www.biotrend-usa.com/other-products-186/seriniquinone-22200-69-7-566000900.html_ seriniquinone].<ref name="trzoss"/> The anticancer effect could derive from direct interaction or from protein complexes linked via disulfide bonds to DCD, which was already shown for [http://proteopedia.org/wiki/index.php/Hsp70_ Hsp70]. In the survival-promoting peptide area of dermcidin, GNPCH is considered to be an ATP-dependent binding-site for Hsp70.<ref> Stocki, P., Wang, X.N., Morris, N.J., Dickinson, A.M., 2011. HSP70 Natively and Specifically Associates with an N-terminal Dermcidin-derived Peptide That Contains an HLA-A*03 Antigenic Epitope. J. Biol. Chem. 286, 12803–12811. https://doi.org/10.1074/jbc.M110.179630 </ref> | ||
== References == | == References == | ||
<references /> | <references /> | ||
