6lpf: Difference between revisions
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The entry | ==The crystal structure of human cytoplasmic LRS== | ||
<StructureSection load='6lpf' size='340' side='right'caption='[[6lpf]], [[Resolution|resolution]] 2.49Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6lpf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LPF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6LPF FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LSS:5-O-(L-LEUCYLSULFAMOYL)ADENOSINE'>LSS</scene>, <scene name='pdbligand=VRT:2-(L-NORVALYL)AMINO-2-DEOXYADENOSINE'>VRT</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leucine--tRNA_ligase Leucine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.4 6.1.1.4] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6lpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lpf OCA], [http://pdbe.org/6lpf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lpf RCSB], [http://www.ebi.ac.uk/pdbsum/6lpf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lpf ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/SYLC_HUMAN SYLC_HUMAN]] Acute infantile liver failure-multisystemic involvement syndrome. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/SYLC_HUMAN SYLC_HUMAN]] Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs.<ref>PMID:19426743</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Leucine--tRNA ligase]] | |||
[[Category: Cusack, S]] | |||
[[Category: Li, H]] | |||
[[Category: Li, J]] | |||
[[Category: Lin, J Z]] | |||
[[Category: Liu, R J]] | |||
[[Category: Long, T]] | |||
[[Category: Palencia, A]] | |||
[[Category: Wang, E D]] | |||
[[Category: Wang, M Z]] | |||
[[Category: Zhao, J H]] | |||
[[Category: Aminoacylation]] | |||
[[Category: Leur]] | |||
[[Category: Protein translation]] | |||
[[Category: Rna binding protein]] | |||
[[Category: Trna]] | |||
