6tug: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6tug is ~~ON HOLD~~

==Enterococcus italicus Csm6 bound to cyclic hexa-2'-fluoro-hexa-dAMP==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6tug]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TUG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TUG FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AF2:2-DEOXY-2-FLUOROADENOSINE+5-(DIHYDROGEN+PHOSPHATE)'>AF2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6tug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tug OCA], [http://pdbe.org/6tug PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tug RCSB], [http://www.ebi.ac.uk/pdbsum/6tug PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tug ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/CSM6_ENTI1 CSM6_ENTI1]] CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (Probable). The type III-A Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate to the crRNA is required for all activities. In a heterologous host the appropriately targeted Csm effector complex prevents growth of dsDNA phage phiNM1-gamma6. This protein is not part of the Csm effector complex (PubMed:28722012).<ref>PMID:28722012</ref> A single-strand-specific endoribonuclease (ssRNase) (PubMed:28722012). Activity is stimulated by cyclic oligoadenylates (cOA); maximal stimulation is seen with cyclic hexaadenylate (cA6) (PubMed:28722012).<ref>PMID:28722012</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Garcia-Doval, C]]

[[Category: Jinek, M]]

[[Category: Crispr]]

[[Category: Cyclic oligoadenylate]]

[[Category: Nuclease]]

[[Category: Rna binding protein]]

[[Category: Rnase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6tug is ON HOLD
+==Enterococcus italicus Csm6 bound to cyclic hexa-2'-fluoro-hexa-dAMP==
+<StructureSection load='6tug' size='340' side='right'caption='[[6tug]], [[Resolution|resolution]] 2.42&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6tug]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TUG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TUG FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AF2:2-DEOXY-2-FLUOROADENOSINE+5-(DIHYDROGEN+PHOSPHATE)'>AF2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6tug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tug OCA], [http://pdbe.org/6tug PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tug RCSB], [http://www.ebi.ac.uk/pdbsum/6tug PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tug ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/CSM6_ENTI1 CSM6_ENTI1]] CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (Probable). The type III-A Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate to the crRNA is required for all activities. In a heterologous host the appropriately targeted Csm effector complex prevents growth of dsDNA phage phiNM1-gamma6. This protein is not part of the Csm effector complex (PubMed:28722012).<ref>PMID:28722012</ref>   A single-strand-specific endoribonuclease (ssRNase) (PubMed:28722012). Activity is stimulated by cyclic oligoadenylates (cOA); maximal stimulation is seen with cyclic hexaadenylate (cA6) (PubMed:28722012).<ref>PMID:28722012</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Garcia-Doval, C]]
+[[Category: Jinek, M]]
+[[Category: Crispr]]
+[[Category: Cyclic oligoadenylate]]
+[[Category: Nuclease]]
+[[Category: Rna binding protein]]
+[[Category: Rnase]]