6tw2: Difference between revisions
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==Re-refined crystal structure of di-phosphorylated human CLK1 in complex with a novel substituted indole inhibitor== | |||
<StructureSection load='6tw2' size='340' side='right'caption='[[6tw2]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6tw2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TW2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TW2 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=V25:ETHYL+3-[(E)-2-AMINO-1-CYANOETHENYL]-6,7-DICHLORO-1-METHYL-1H-INDOLE-2-CARBOXYLATE'>V25</scene></td></tr> | |||
[[Category: | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vag|2vag]]</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6tw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tw2 OCA], [http://pdbe.org/6tw2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tw2 RCSB], [http://www.ebi.ac.uk/pdbsum/6tw2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tw2 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/CLK1_HUMAN CLK1_HUMAN]] Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.<ref>PMID:10480872</ref> <ref>PMID:19168442</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Dual-specificity kinase]] | |||
[[Category: Large Structures]] | |||
[[Category: Haltenhof, T]] | |||
[[Category: Heyd, F]] | |||
[[Category: Loll, B]] | |||
[[Category: Wahl, M C]] | |||
[[Category: Nucleus]] | |||
[[Category: Serine/threonine-protein kinase]] | |||
[[Category: Transferase]] | |||
[[Category: Tyrosine-protein kinase]] | |||
Revision as of 08:11, 5 February 2020
Re-refined crystal structure of di-phosphorylated human CLK1 in complex with a novel substituted indole inhibitor
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