6s22: Difference between revisions

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<StructureSection load='6s22' size='340' side='right'caption='[[6s22]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
<StructureSection load='6s22' size='340' side='right'caption='[[6s22]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6s22]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Poephila_guttata Poephila guttata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S22 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6S22 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6s22]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Taeniopygia_guttata Taeniopygia guttata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S22 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6S22 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GALNT3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=59729 Poephila guttata])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6s22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s22 OCA], [http://pdbe.org/6s22 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s22 RCSB], [http://www.ebi.ac.uk/pdbsum/6s22 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s22 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6s22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s22 OCA], [https://pdbe.org/6s22 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6s22 RCSB], [https://www.ebi.ac.uk/pdbsum/6s22 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6s22 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/FGF23_HUMAN FGF23_HUMAN]] Defects in FGF23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR) [MIM:[http://omim.org/entry/193100 193100]]. ADHR is characterized by low serum phosphorus concentrations, rickets, osteomalacia, leg deformities, short stature, bone pain and dental abscesses.<ref>PMID:11062477</ref> <ref>PMID:11409890</ref> <ref>PMID:16638743</ref>  Defects in FGF23 are a cause of hyperphosphatemic familial tumoral calcinosis (HFTC) [MIM:[http://omim.org/entry/211900 211900]]. HFTC is a severe autosomal recessive metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues.<ref>PMID:15590700</ref> 
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/FGF23_HUMAN FGF23_HUMAN]] Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization.<ref>PMID:11062477</ref> <ref>PMID:11409890</ref> <ref>PMID:15040831</ref> <ref>PMID:16597617</ref> <ref>PMID:18282132</ref>
[https://www.uniprot.org/uniprot/GALT3_TAEGU GALT3_TAEGU] Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor (PubMed:31932717). Glycosylates FGF23 (PubMed:31932717).<ref>PMID:31932717</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6s22" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6s22" style="background-color:#fffaf0;"></div>
==See Also==
*[[Fibroblast growth factor 3D structures|Fibroblast growth factor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Poephila guttata]]
[[Category: Taeniopygia guttata]]
[[Category: Bernado, P]]
[[Category: Bernado P]]
[[Category: Ceballos-Laita, L]]
[[Category: Ceballos-Laita L]]
[[Category: Clausen, H]]
[[Category: Clausen H]]
[[Category: Coelho, H]]
[[Category: Coelho H]]
[[Category: Companon, I]]
[[Category: Companon I]]
[[Category: Corzana, F]]
[[Category: Corzana F]]
[[Category: Daniel, E J.P]]
[[Category: Daniel EJP]]
[[Category: Gerken, T A]]
[[Category: Gerken TA]]
[[Category: Hansen, L]]
[[Category: Hansen L]]
[[Category: Hermosilla, P]]
[[Category: Hermosilla P]]
[[Category: Hurtado-Guerrero, R]]
[[Category: Hurtado-Guerrero R]]
[[Category: Kato, K]]
[[Category: Kato K]]
[[Category: Lostao, A]]
[[Category: Lostao A]]
[[Category: Marcelo, F]]
[[Category: Marcelo F]]
[[Category: Narimatsu, Y]]
[[Category: Narimatsu Y]]
[[Category: Rivas, M de las]]
[[Category: Thureau A]]
[[Category: Thureau, A]]
[[Category: De las Rivas M]]
[[Category: Enzyme kinetic]]
[[Category: Fgf23]]
[[Category: Galnac-t]]
[[Category: Galnac-t3]]
[[Category: Long-range glycosylation preference]]
[[Category: Molecular dynamic]]
[[Category: Phosphate homeostasis]]
[[Category: Specificity]]
[[Category: Transferase]]
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