1ae7: Difference between revisions

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[[Image:1ae7.~~gif~~|left|200px]]

[[Image:1ae7.png|left|200px]]

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~~'''~~NOTEXIN, A PRESYNAPTIC NEUROTOXIC PHOSPHOLIPASE A2~~'''~~

===NOTEXIN, A PRESYNAPTIC NEUROTOXIC PHOSPHOLIPASE A2===

~~==Overview==~~

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~~The three-dimensional structure of notexin has been solved by molecular replacement methods. The structure has been refined at 2.0 A resolution to a crystallographic R~~-~~value of 16.5% with good stereo~~-~~chemistry. The core of the protein is very similar to other phospholipase A2s (PLA2 s) but several parts of the molecule are distinctly different.~~ The ~~most significant differences from PLA2 s from bovine pancreas and rattlesnake occur in the stretches 56-80 and 85-89. Residue 69~~, ~~which has been shown to be important for phospholipase binding~~, ~~has a different conformation and different interactions than in other known PLA2s. The C alpha positions for residues 86-88 differ by about 6 A from both~~ the ~~bovine and~~ the ~~rattlesnake enzyme~~. ~~The crystals contain no Ca2+ ions~~. ~~Instead~~, ~~a water molecule occupies~~ the ~~calcium site~~.

The line below this paragraph, {{ABSTRACT_PUBMED_1568473}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 1568473 is the PubMed ID number.

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==About this Structure==

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[[Category: Presynaptic neurotoxin]]

[[Category: Venom]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 10~~:09:10 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:39:42 2008''

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-[[Image:1ae7.gif|left|200px]]
+{{Seed}}
+[[Image:1ae7.png|left|200px]]
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 {{STRUCTURE_1ae7|  PDB=1ae7  |  SCENE=  }}
-'''NOTEXIN, A PRESYNAPTIC NEUROTOXIC PHOSPHOLIPASE A2'''
+===NOTEXIN, A PRESYNAPTIC NEUROTOXIC PHOSPHOLIPASE A2===
-==Overview==
+<!--
-The three-dimensional structure of notexin has been solved by molecular replacement methods. The structure has been refined at 2.0 A resolution to a crystallographic R-value of 16.5% with good stereo-chemistry. The core of the protein is very similar to other phospholipase A2s (PLA2 s) but several parts of the molecule are distinctly different. The most significant differences from PLA2 s from bovine pancreas and rattlesnake occur in the stretches 56-80 and 85-89. Residue 69, which has been shown to be important for phospholipase binding, has a different conformation and different interactions than in other known PLA2s. The C alpha positions for residues 86-88 differ by about 6 A from both the bovine and the rattlesnake enzyme. The crystals contain no Ca2+ ions. Instead, a water molecule occupies the calcium site.
+The line below this paragraph, {{ABSTRACT_PUBMED_1568473}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 1568473 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_1568473}}
 ==About this Structure==
@@ Line 32: / Line 36: @@
 [[Category: Presynaptic neurotoxin]]
 [[Category: Venom]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:09:10 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:39:42 2008''