6ul4: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6ul4 is ~~ON HOLD until Paper Publication~~

==Crystal structure of BoNT/B receptor-binding domain in complex with VHH JLO-G11==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6ul4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UL4 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UL4 FirstGlance].

~~Description~~:

</td></tr><tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Bontoxilysin Bontoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.69 3.4.24.69] </td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ul4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ul4 OCA], [http://pdbe.org/6ul4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ul4 RCSB], [http://www.ebi.ac.uk/pdbsum/6ul4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ul4 ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/BXB_CLOBO BXB_CLOBO]] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2.

__TOC__

</StructureSection>

[[Category: Bontoxilysin]]

[[Category: Large Structures]]

[[Category: Jin, R]]

[[Category: Lam, K]]

[[Category: Antitoxin]]

[[Category: Receptor-binding domain]]

[[Category: Toxin]]

[[Category: Toxin-antitoxin complex]]

[[Category: Vhh]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6ul4 is ON HOLD  until Paper Publication
+==Crystal structure of BoNT/B receptor-binding domain in complex with VHH JLO-G11==
+<StructureSection load='6ul4' size='340' side='right'caption='[[6ul4]], [[Resolution|resolution]] 3.18&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6ul4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UL4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UL4 FirstGlance]. <br>
-Description:
+</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Bontoxilysin Bontoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.69 3.4.24.69] </span></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ul4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ul4 OCA], [http://pdbe.org/6ul4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ul4 RCSB], [http://www.ebi.ac.uk/pdbsum/6ul4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ul4 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/BXB_CLOBO BXB_CLOBO]] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2.
+__TOC__
+</StructureSection>
+[[Category: Bontoxilysin]]
+[[Category: Large Structures]]
+[[Category: Jin, R]]
+[[Category: Lam, K]]
+[[Category: Antitoxin]]
+[[Category: Receptor-binding domain]]
+[[Category: Toxin]]
+[[Category: Toxin-antitoxin complex]]
+[[Category: Vhh]]