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==Crystal structure of 14-3-3sigma in complex with a RapGef2 pT740 phosphopeptide inhibited by semi-synthetic fusicoccane FC-NCPC==
==Crystal structure of 14-3-3sigma in complex with a RapGef2 pT740 phosphopeptide inhibited by semi-synthetic fusicoccane FC-NCPC==
<StructureSection load='6qdu' size='340' side='right'caption='[[6qdu]], [[Resolution|resolution]] 1.63&Aring;' scene=''>
<StructureSection load='6qdu' size='340' side='right'caption='[[6qdu]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6qdu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QDU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QDU FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QDU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6QDU FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HY5:FC-NCPC'>HY5</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qdu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qdu OCA], [https://pdbe.org/6qdu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qdu RCSB], [https://www.ebi.ac.uk/pdbsum/6qdu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qdu ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qdu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qdu OCA], [http://pdbe.org/6qdu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qdu RCSB], [http://www.ebi.ac.uk/pdbsum/6qdu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qdu ProSAT]</span></td></tr>
</table>
</table>
== Function ==
 
[[http://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity).  p53-regulated inhibitor of G2/M progression.
==See Also==
*[[14-3-3 protein 3D structures|14-3-3 protein 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Andrei, S A]]
[[Category: Andrei SA]]
[[Category: Fournier, A E]]
[[Category: Fournier AE]]
[[Category: Kaplan, A]]
[[Category: Kaplan A]]
[[Category: Ottman, C]]
[[Category: Ottman C]]
[[Category: Chaperone]]
[[Category: Neuron regeneration]]
[[Category: Phosphorylation]]
[[Category: Ppi]]

Revision as of 06:13, 11 August 2021

Crystal structure of 14-3-3sigma in complex with a RapGef2 pT740 phosphopeptide inhibited by semi-synthetic fusicoccane FC-NCPC

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