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| {{STRUCTURE_1af3| PDB=1af3 | SCENE= }} | | {{STRUCTURE_1af3| PDB=1af3 | SCENE= }} |
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| '''RAT BCL-XL AN APOPTOSIS INHIBITORY PROTEIN'''
| | ===RAT BCL-XL AN APOPTOSIS INHIBITORY PROTEIN=== |
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| ==Overview==
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| Bcl-xL is a member of the Bcl-2 protein family, which regulates apoptosis. Preparation of recombinant rat Bcl-xL yielded two forms, one deamidated at -Asn-Gly- sequences to produce isoaspartates and the other not deamidated. The crystal structures of the two forms show that they both adopt an essentially identical backbone structure which resembles the fold of human Bcl-xL: three layers of two alpha-helices each, capped at one end by two short helices. Both forms have a long disordered region, which contains the potential deamidation sites. The molecular structure exhibits a low level of interhelical interactions, the presence of three cavities, and a notable hydrophobic cleft surrounded by walls rich in basic residues. These unique structural features may be favorable for its accommodation into membranes or for possible rearrangement to modulate homo-/heterodimerization. Homology modeling of Bcl-2 and Bax, based on the Bcl-xL structure, suggests that Bax has the strongest potential for membrane insertion. Furthermore, we found a possible interface for interaction with non-Bcl-2 family member proteins, such as CED-4 homologues.
| | The line below this paragraph, {{ABSTRACT_PUBMED_9346936}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 9346936 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_9346936}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Mitochondrion]] | | [[Category: Mitochondrion]] |
| [[Category: Regulatory protein]] | | [[Category: Regulatory protein]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:11:06 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:42:49 2008'' |
