1af6: Difference between revisions

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[[Image:1af6.gif|left|200px]]
{{Seed}}
[[Image:1af6.png|left|200px]]


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{{STRUCTURE_1af6|  PDB=1af6  |  SCENE=  }}  
{{STRUCTURE_1af6|  PDB=1af6  |  SCENE=  }}  


'''MALTOPORIN SUCROSE COMPLEX'''
===MALTOPORIN SUCROSE COMPLEX===




==Overview==
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Maltoporin (LamB) facilitates the diffusion of maltodextrins across the outer membrane of E. coli. The structural basis for the specificity of the channel is investigated by X-ray structure analysis of maltoporin in complex with the disaccharides sucrose, trehalose, and melibiose. The sucrose complex, determined to 2.4 A resolution, shows that the glucosyl moiety is partly inserted into the channel constriction, while the bulky fructosyl residue appears to be hindered to enter the constriction, thus interfering with its further translocation. One of the glucosyl moieties of trehalose is found in a similar position as the glucosyl moiety of sucrose, whereas melibiose appears disordered when bound to maltoporin. A comparison with the previously reported maltoporin-maltose complex sheds light on the basis for sugar discrimination, and explains the different permeation rates observed for the saccharides.
The line below this paragraph, {{ABSTRACT_PUBMED_9299337}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_9299337}}


==About this Structure==
==About this Structure==
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[[Category: Sucrose]]
[[Category: Sucrose]]
[[Category: Sugar transport]]
[[Category: Sugar transport]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:11:20 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:43:18 2008''

Revision as of 13:43, 30 June 2008

File:1af6.png

Template:STRUCTURE 1af6

MALTOPORIN SUCROSE COMPLEX

Template:ABSTRACT PUBMED 9299337

About this Structure

1AF6 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Channel specificity: structural basis for sugar discrimination and differential flux rates in maltoporin., Wang YF, Dutzler R, Rizkallah PJ, Rosenbusch JP, Schirmer T, J Mol Biol. 1997 Sep 12;272(1):56-63. PMID:9299337

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