5qu8: Difference between revisions
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==Crystal Structure of symmetric swapped human Nck SH3.1 domain, 0.93A, orthorhombic form IV== | |||
<StructureSection load='5qu8' size='340' side='right'caption='[[5qu8]], [[Resolution|resolution]] 0.93Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5qu8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QU8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QU8 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qu8 OCA], [http://pdbe.org/5qu8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qu8 RCSB], [http://www.ebi.ac.uk/pdbsum/5qu8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qu8 ProSAT]</span></td></tr> | ||
[[Category: Rudolph, M | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/NCK1_HUMAN NCK1_HUMAN]] Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.<ref>PMID:10026169</ref> <ref>PMID:16835242</ref> <ref>PMID:17803907</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Rudolph, M G]] | |||
[[Category: Adaptor]] | |||
[[Category: Domain swap]] | |||
[[Category: Peptide binding]] | |||
[[Category: Sh3 domain]] | |||
[[Category: Signaling protein]] | |||
Revision as of 04:06, 13 February 2020
Crystal Structure of symmetric swapped human Nck SH3.1 domain, 0.93A, orthorhombic form IV
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