1afx: Difference between revisions

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[[Image:1afx.~~jpg~~|left|200px]]

[[Image:1afx.png|left|200px]]

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~~'''~~UGAA EUKARYOTIC RIBOSOMAL RNA TETRALOOP, NMR, 13 STRUCTURES~~'''~~

===UGAA EUKARYOTIC RIBOSOMAL RNA TETRALOOP, NMR, 13 STRUCTURES===

~~==Overview==~~

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The ~~hairpin ribozyme is a small catalytic RNA with a unique two-domain structure. Here we present the solution structure of the loop B domain of the hairpin ribozyme~~, ~~which contains most of~~ the ~~catalytically essential nucleotides. The 38-nucleotide domain contains a 16-nucleotide internal loop that forms one of~~ the ~~largest non-Watson-Crick segments of base pairing thus far determined by either NMR or crystallography~~. Since the solution structure of the smaller loop A domain has been previously solved, an NMR structure-based model of the 22,000 Mr hairpin ribozyme-substrate open complex emerges by joining the two domain structures. ~~Strikingly~~, ~~catalytically essential functional groups for the loop B domain are concentrated within an expanded minor groove, presenting a clear docking surface for~~ the ~~loop A domain~~.

The line below this paragraph, {{ABSTRACT_PUBMED_10074938}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10074938 is the PubMed ID number.

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==About this Structure==

Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AFX OCA].

Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AFX OCA].

==Reference==

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[[Category: Ribosomal rna]]

[[Category: Tetraloop]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 10~~:13:01 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:45:57 2008''

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-[[Image:1afx.jpg|left|200px]]
+{{Seed}}
+[[Image:1afx.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1afx|  PDB=1afx  |  SCENE=  }}
-'''UGAA EUKARYOTIC RIBOSOMAL RNA TETRALOOP, NMR, 13 STRUCTURES'''
+===UGAA EUKARYOTIC RIBOSOMAL RNA TETRALOOP, NMR, 13 STRUCTURES===
-==Overview==
+<!--
-The hairpin ribozyme is a small catalytic RNA with a unique two-domain structure. Here we present the solution structure of the loop B domain of the hairpin ribozyme, which contains most of the catalytically essential nucleotides. The 38-nucleotide domain contains a 16-nucleotide internal loop that forms one of the largest non-Watson-Crick segments of base pairing thus far determined by either NMR or crystallography. Since the solution structure of the smaller loop A domain has been previously solved, an NMR structure-based model of the 22,000 Mr hairpin ribozyme-substrate open complex emerges by joining the two domain structures. Strikingly, catalytically essential functional groups for the loop B domain are concentrated within an expanded minor groove, presenting a clear docking surface for the loop A domain.
+The line below this paragraph, {{ABSTRACT_PUBMED_10074938}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10074938 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10074938}}
 ==About this Structure==
-Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AFX OCA].
+Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AFX OCA].
 ==Reference==
@@ Line 26: / Line 30: @@
 [[Category: Ribosomal rna]]
 [[Category: Tetraloop]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:13:01 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:45:57 2008''