6xy7: Difference between revisions
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==Human SHIP1 with magnesium and phosphate bound to the active site== | |||
<StructureSection load='6xy7' size='340' side='right'caption='[[6xy7]], [[Resolution|resolution]] 1.09Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6xy7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XY7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6XY7 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6xy7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xy7 OCA], [http://pdbe.org/6xy7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xy7 RCSB], [http://www.ebi.ac.uk/pdbsum/6xy7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xy7 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/SHIP1_HUMAN SHIP1_HUMAN]] Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6.<ref>PMID:12421919</ref> <ref>PMID:16682172</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Arrowsmith, C H]] | |||
[[Category: Bountra, C]] | |||
[[Category: Bradshaw, W J]] | |||
[[Category: Burgess-Brown, N A]] | |||
[[Category: Delft, F von]] | |||
[[Category: Edwards, A M]] | |||
[[Category: Fernandez-Cid, A]] | [[Category: Fernandez-Cid, A]] | ||
[[Category: Gileadi, O]] | [[Category: Gileadi, O]] | ||
[[Category: Mckinley, G]] | [[Category: Mckinley, G]] | ||
[[Category: Scacioc, A]] | |||
[[Category: Alzheimer's disease]] | |||
[[Category: Hydrolase]] | |||
[[Category: Phosphatase]] | |||
[[Category: Phosphate]] | |||
[[Category: Phosphatidylinositol]] | |||
