1agi: Difference between revisions

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[[Image:1agi.gif|left|200px]]
{{Seed}}
[[Image:1agi.png|left|200px]]


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{{STRUCTURE_1agi|  PDB=1agi  |  SCENE=  }}  
{{STRUCTURE_1agi|  PDB=1agi  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF BOVINE ANGIOGENIN AT 1.5 ANGSTROMS RESOLUTION'''
===CRYSTAL STRUCTURE OF BOVINE ANGIOGENIN AT 1.5 ANGSTROMS RESOLUTION===




==Overview==
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The capacity of angiogenin (Ang) to induce blood vessel growth is critically dependent on its ribonucleolytic activity. Crystallography and mutagenesis of human Ang have previously shown that its pyrimidine binding site is obstructed by Gln-117, implying that a conformational change is a key part of the mechanism of Ang action. The 1.5-A-resolution crystal structure of bovine Ang, in which glutamic acid is substituted for Gln-117, now confirms that a blocked active site is characteristic of these proteins. Indeed, the inactive conformation of bovine Ang is stabilized by a more extensive set of interactions than is that of human Ang. The three-dimensional structure of the putative receptor binding site is also well conserved in the two proteins. The Arg-Gly-Asp segment of this site in bovine Ang, which is replaced by Arg-Glu-Asn in human Ang, does not have a conformation typical of an integrin recognition site.
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{{ABSTRACT_PUBMED_7708754}}


==About this Structure==
==About this Structure==
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[[Category: Vallee, B L.]]
[[Category: Vallee, B L.]]
[[Category: Endonuclease]]
[[Category: Endonuclease]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:14:20 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:48:05 2008''

Revision as of 13:48, 30 June 2008

File:1agi.png

Template:STRUCTURE 1agi

CRYSTAL STRUCTURE OF BOVINE ANGIOGENIN AT 1.5 ANGSTROMS RESOLUTION

Template:ABSTRACT PUBMED 7708754

About this Structure

1AGI is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Crystal structure of bovine angiogenin at 1.5-A resolution., Acharya KR, Shapiro R, Riordan JF, Vallee BL, Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2949-53. PMID:7708754

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