1ah8: Difference between revisions

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[[Image:1ah8.gif|left|200px]]
{{Seed}}
[[Image:1ah8.png|left|200px]]


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{{STRUCTURE_1ah8|  PDB=1ah8  |  SCENE=  }}  
{{STRUCTURE_1ah8|  PDB=1ah8  |  SCENE=  }}  


'''STRUCTURE OF THE ORTHORHOMBIC FORM OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE'''
===STRUCTURE OF THE ORTHORHOMBIC FORM OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE===




==Overview==
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Hsp90 is a highly specific chaperone for many signal transduction proteins, including steroid hormone receptors and a broad range of protein kinases. The crystal structure of the N-terminal domain of the yeast Hsp90 reveals a dimeric structure based on a highly twisted sixteen stranded beta-sheet, whose topology suggests a possible 30-domain-swapped structure for the intact Hsp90 dimer. The opposing faces of the beta-sheets in the dimer define a potential peptide-binding cleft, suggesting that the N-domain may serve as a molecular 'clamp' in the binding of ligand proteins to Hsp90.
The line below this paragraph, {{ABSTRACT_PUBMED_9187656}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9187656 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9187656}}


==About this Structure==
==About this Structure==
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[[Category: Chaperone]]
[[Category: Chaperone]]
[[Category: Heat shock]]
[[Category: Heat shock]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:16:05 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:50:42 2008''

Revision as of 13:50, 30 June 2008

File:1ah8.png

Template:STRUCTURE 1ah8

STRUCTURE OF THE ORTHORHOMBIC FORM OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE

Template:ABSTRACT PUBMED 9187656

About this Structure

1AH8 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone., Prodromou C, Roe SM, Piper PW, Pearl LH, Nat Struct Biol. 1997 Jun;4(6):477-82. PMID:9187656

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