4j4l: Difference between revisions

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<StructureSection load='4j4l' size='340' side='right'caption='[[4j4l]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='4j4l' size='340' side='right'caption='[[4j4l]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4j4l]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J4L FirstGlance]. <br>
<table><tr><td colspan='2'>[[4j4l]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Eptatretus_burgeri Eptatretus burgeri], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J4L FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4l OCA], [http://pdbe.org/4j4l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4j4l RCSB], [http://www.ebi.ac.uk/pdbsum/4j4l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4j4l ProSAT]</span></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4l OCA], [https://pdbe.org/4j4l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j4l RCSB], [https://www.ebi.ac.uk/pdbsum/4j4l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j4l ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/IL6_HUMAN IL6_HUMAN]] Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.  Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/IL6_HUMAN IL6_HUMAN]] Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.  
[https://www.uniprot.org/uniprot/Q4G1L3_EPTBU Q4G1L3_EPTBU] [https://www.uniprot.org/uniprot/A4L9V2_LISMN A4L9V2_LISMN]


==See Also==
==See Also==
*[[Interleukin 3D structures|Interleukin 3D structures]]
*[[Interleukin 3D structures|Interleukin 3D structures]]
*[[Variable lymphocyte receptor|Variable lymphocyte receptor]]
*[[Variable lymphocyte receptor 3D structures|Variable lymphocyte receptor 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Eptatretus burgeri]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Cheong, H K]]
[[Category: Listeria monocytogenes]]
[[Category: Kim, H J]]
[[Category: Synthetic construct]]
[[Category: Extracellular matrix]]
[[Category: Cheong HK]]
[[Category: Il-6 binding]]
[[Category: Kim HJ]]
[[Category: Interleukin 6]]
[[Category: Lrr]]
[[Category: Protein binding-cytokine complex]]
Retrieved from "https://proteopedia.org/4j4l"