6vja: Difference between revisions
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The | ==Structure of CD20 in complex with rituximab Fab== | ||
<StructureSection load='6vja' size='340' side='right'caption='[[6vja]], [[Resolution|resolution]] 3.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6vja]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VJA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6VJA FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6vja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vja OCA], [http://pdbe.org/6vja PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vja RCSB], [http://www.ebi.ac.uk/pdbsum/6vja PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vja ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/CD20_HUMAN CD20_HUMAN]] Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5) [MIM:[http://omim.org/entry/613495 613495]]; also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.<ref>PMID:20038800</ref> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/CD20_HUMAN CD20_HUMAN]] This protein may be involved in the regulation of B-cell activation and proliferation. | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Croll, T I]] | |||
[[Category: Rohou, A]] | |||
[[Category: Antibody]] | |||
[[Category: Cd20]] | |||
[[Category: Human]] | |||
[[Category: Immune system]] | |||
[[Category: Ms4a1]] | |||
[[Category: Rituximab]] | |||
[[Category: Therapeutic]] | |||
Revision as of 09:28, 26 February 2020
Structure of CD20 in complex with rituximab Fab
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