4oo2: Difference between revisions

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<StructureSection load='4oo2' size='340' side='right'caption='[[4oo2]], [[Resolution|resolution]] 2.63&Aring;' scene=''>
<StructureSection load='4oo2' size='340' side='right'caption='[[4oo2]], [[Resolution|resolution]] 2.63&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4oo2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_globisporus"_krasil'nikov_1941 "actinomyces globisporus" krasil'nikov 1941]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OO2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OO2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4oo2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_globisporus Streptomyces globisporus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OO2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OO2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oo2 OCA], [https://pdbe.org/4oo2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oo2 RCSB], [https://www.ebi.ac.uk/pdbsum/4oo2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oo2 ProSAT]</span></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4r82|4r82]], [[4hx6|4hx6]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oo2 OCA], [http://pdbe.org/4oo2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4oo2 RCSB], [http://www.ebi.ac.uk/pdbsum/4oo2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4oo2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SGCC_STRGL SGCC_STRGL] Oxygenase component of a two-component system involved in the biosynthesis of the enediyne antitumor antibiotic C-1027 (PubMed:18426211). Uses FADH(2) supplied by SgcE6 to catalyze the C-5 hydroxylation of (S)-3-chloro-beta-tyrosyl-S-SgcC2 (PubMed:18426211). Can also efficiently catalyze the regioselective hydroxylation of other 3-substituted beta-tyrosyl-S-SgcC2 analogs, including the bromo-, iodo-, fluoro-, and methyl-substituted analogs, but does not accept 3-hydroxy-beta-tyrosyl-S-SgcC2 as a substrate (PubMed:18426211). Is only active with SgcC2 (peptidyl carrier protein)-tethered substrates (PubMed:18426211).<ref>PMID:18426211</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Actinomyces globisporus krasil'nikov 1941]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Bingman, C]]
[[Category: Streptomyces globisporus]]
[[Category: Cao, H]]
[[Category: Bingman C]]
[[Category: Lohman, J R]]
[[Category: Cao H]]
[[Category: NatPro, Enzyme Discovery for Natural Product Biosynthesis]]
[[Category: Lohman JR]]
[[Category: Phillips, G N]]
[[Category: Phillips Jr GN]]
[[Category: Shen, B]]
[[Category: Shen B]]
[[Category: Xu, W]]
[[Category: Xu W]]
[[Category: Yennamalli, R]]
[[Category: Yennamalli R]]
[[Category: Enzyme discovery for natural product biosynthesis]]
[[Category: Fad binding]]
[[Category: Natpro]]
[[Category: Oxidoreductase]]
[[Category: Psi-biology]]
[[Category: Putative hpab-family monooxygenase]]
[[Category: Structural genomic]]
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