1ak6: Difference between revisions

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[[Image:1ak6.gif|left|200px]]
{{Seed}}
[[Image:1ak6.png|left|200px]]


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{{STRUCTURE_1ak6|  PDB=1ak6  |  SCENE=  }}  
{{STRUCTURE_1ak6|  PDB=1ak6  |  SCENE=  }}  


'''DESTRIN, NMR, MINIMIZED AVERAGE STRUCTURE'''
===DESTRIN, NMR, MINIMIZED AVERAGE STRUCTURE===




==Overview==
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Destrin is an isoprotein of cofilin that regulates actin cytoskeleton in various eukaryotes. We determined the tertiary structure of destrin by triple-resonance multidimensional nuclear magnetic resonance. In spite of there being no significant amino acid sequence homology, we found that the folding of destrin was strikingly similar to that of repeated segments in the gelsolin family, which resulted in a new protein fold group. Sequential dissimilarity of the actin-binding helix of destrin to that of gelsolin explains the Ca2+-independent actin-binding of destrin. Possible mechanisms of phosphorylation-sensitive phosphoinositide-competitive actin binding, of pH-dependent filament severing, and of nuclear translocation with actin in response to stresses, are discussed on the basis of the tertiary structure.
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{{ABSTRACT_PUBMED_8674111}}


==About this Structure==
==About this Structure==
1AK6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens_and_sus_scrofa Homo sapiens and sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AK6 OCA].  
1AK6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens_and_sus_scrofa Homo sapiens and sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AK6 OCA].  


==Reference==
==Reference==
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[[Category: Actin depolymerization factor]]
[[Category: Actin depolymerization factor]]
[[Category: Actin-binding protein]]
[[Category: Actin-binding protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:22:32 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:01:20 2008''

Revision as of 14:01, 30 June 2008

File:1ak6.png

Template:STRUCTURE 1ak6

DESTRIN, NMR, MINIMIZED AVERAGE STRUCTURE

Template:ABSTRACT PUBMED 8674111

About this Structure

1AK6 is a Single protein structure of sequence from Homo sapiens and sus scrofa. Full experimental information is available from OCA.

Reference

Tertiary structure of destrin and structural similarity between two actin-regulating protein families., Hatanaka H, Ogura K, Moriyama K, Ichikawa S, Yahara I, Inagaki F, Cell. 1996 Jun 28;85(7):1047-55. PMID:8674111

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