1aly: Difference between revisions

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[[Image:1aly.gif|left|200px]]
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[[Image:1aly.png|left|200px]]


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{{STRUCTURE_1aly|  PDB=1aly  |  SCENE=  }}  
{{STRUCTURE_1aly|  PDB=1aly  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF HUMAN CD40 LIGAND'''
===CRYSTAL STRUCTURE OF HUMAN CD40 LIGAND===




==Overview==
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BACKGROUND: The CD40 ligand (CD40L) is a member of the tumor necrosis factor (TNF) family of proteins and is transiently expressed on the surface of activated T cells. The binding of CD40L to CD40, which is expressed on the surface of B cells, provides a critical and unique pathway of cellular activation resulting in antibody isotype switching, regulation of apoptosis, and B cell proliferation and differentiation. Naturally occurring mutations of CD40L result in the clinical hyper-IgM syndrome, characterized by an inability to produce immunoglobulins of the IgG, IgA and IgE isotypes. RESULTS: We have determined the crystal structure of a soluble extracellular fragment of human CD40L to 2 A resolution and with an R factor of 21.8%. Although the molecule forms a trimer similar to that found for other members of the TNF family, such as TNF alpha and lymphotoxin-alpha, and exhibits a similar overall fold, there are considerable differences in several loops including those predicted to be involved in CD40 binding. CONCLUSIONS: The structure suggests that most of the hyper-IgM syndrome mutations affect the folding and stability of the molecule rather than the CD40-binding site directly. Despite the fact that the hyper-IgM syndrome mutations are dispersed in the primary sequence, a large fraction of them are clustered in space in the vicinity of a surface loop, close to the predicted CD40-binding site.
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{{ABSTRACT_PUBMED_8589998}}


==About this Structure==
==About this Structure==
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[[Category: Hyper-igm syndrome]]
[[Category: Hyper-igm syndrome]]
[[Category: Tnf]]
[[Category: Tnf]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:26:03 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:07:29 2008''

Revision as of 14:07, 30 June 2008

File:1aly.png

Template:STRUCTURE 1aly

CRYSTAL STRUCTURE OF HUMAN CD40 LIGAND

Template:ABSTRACT PUBMED 8589998

About this Structure

1ALY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

2 A crystal structure of an extracellular fragment of human CD40 ligand., Karpusas M, Hsu YM, Wang JH, Thompson J, Lederman S, Chess L, Thomas D, Structure. 1995 Oct 15;3(10):1031-9. PMID:8589998

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