4wvm: Difference between revisions

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<StructureSection load='4wvm' size='340' side='right'caption='[[4wvm]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
<StructureSection load='4wvm' size='340' side='right'caption='[[4wvm]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4wvm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Synanceia_horrida Synanceia horrida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WVM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WVM FirstGlance]. <br>
<table><tr><td colspan='2'>[[4wvm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synanceia_horrida Synanceia horrida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WVM FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wvm OCA], [http://pdbe.org/4wvm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wvm RCSB], [http://www.ebi.ac.uk/pdbsum/4wvm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wvm ProSAT]</span></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wvm OCA], [https://pdbe.org/4wvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wvm RCSB], [https://www.ebi.ac.uk/pdbsum/4wvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wvm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/STXA_SYNHO STXA_SYNHO]] This lethal (towards mice) toxin induces hemolytic activities due to its ability to form pores in the cell membrane, elicits potent hypotension which is endothelium-dependent and appears to be mediated by the nitric oxide pathway and activation of potassium channels, displays edema-inducing activities, increases vascular permeability, induces endothelium-dependent vasorelaxation of isolated rat aorta, induces platelet aggregation, is myotoxic and interferes irreversibly with neuromuscular function.<ref>PMID:1790672</ref> <ref>PMID:8079369</ref> <ref>PMID:9271089</ref>  [[http://www.uniprot.org/uniprot/STXB_SYNHO STXB_SYNHO]] This lethal (towards mice) toxin induces hemolytic activities due to its ability to form pores in the cell membrane, elicits potent hypotension which is endothelium-dependent and appears to be mediated by the nitric oxide pathway and activation of potassium channels, displays edema-inducing activities, increases vascular permeability, induces endothelium-dependent vasorelaxation of isolated rat aorta, induces platelet aggregation, is myotoxic and interferes irreversibly with neuromuscular function.<ref>PMID:1790672</ref> <ref>PMID:8079369</ref> <ref>PMID:9271089</ref>
[https://www.uniprot.org/uniprot/STXA_SYNHO STXA_SYNHO] This lethal (towards mice) toxin induces hemolytic activities due to its ability to form pores in the cell membrane, elicits potent hypotension which is endothelium-dependent and appears to be mediated by the nitric oxide pathway and activation of potassium channels, displays edema-inducing activities, increases vascular permeability, induces endothelium-dependent vasorelaxation of isolated rat aorta, induces platelet aggregation, is myotoxic and interferes irreversibly with neuromuscular function.<ref>PMID:1790672</ref> <ref>PMID:8079369</ref> <ref>PMID:9271089</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Synanceia horrida]]
[[Category: Synanceia horrida]]
[[Category: Ellisdon, A M]]
[[Category: Ellisdon AM]]
[[Category: McGowan, S]]
[[Category: McGowan S]]
[[Category: Panjikar, S]]
[[Category: Panjikar S]]
[[Category: Whisstock, J C]]
[[Category: Whisstock JC]]
[[Category: Cytolysin]]
[[Category: Macpf cdc]]
[[Category: Membrane attack complex]]
[[Category: Perforin cholesterol dependent]]
[[Category: Pry]]
[[Category: Spry]]
[[Category: Thioredoxin focal adhesion targeting]]
[[Category: Toxin]]
[[Category: Venom]]
Retrieved from "https://proteopedia.org/4wvm"