5a1m: Difference between revisions

<table><tr><td colspan='2'>[[5a1m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A1M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A1M FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a1m OCA], [https://pdbe.org/5a1m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a1m RCSB], [https://www.ebi.ac.uk/pdbsum/5a1m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a1m ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/SCIN_HUMAN SCIN_HUMAN] Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed:8547642, PubMed:26365202). Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (By similarity). In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (PubMed:11568009). Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (By similarity). Regulates chondrocyte proliferation and differentiation (By similarity). Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (PubMed:11568009).[UniProtKB:Q28046][UniProtKB:Q5ZIV9][UniProtKB:Q60604]<ref>PMID:11568009</ref> <ref>PMID:26365202</ref> <ref>PMID:8547642</ref>

[[Category: Homo sapiens]]

[[Category: Chumnarnsilpa S]]

[[Category: Grimes JM]]

[[Category: Leyrat C]]

[[Category: Robinson RC]]