1anp: Difference between revisions

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[[Image:1anp.gif|left|200px]]
{{Seed}}
[[Image:1anp.png|left|200px]]


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{{STRUCTURE_1anp|  PDB=1anp  |  SCENE=  }}  
{{STRUCTURE_1anp|  PDB=1anp  |  SCENE=  }}  


'''SOLUTION CONFORMATION OF AN ATRIAL NATRIURETIC PEPTIDE VARIANT SELECTIVE FOR THE TYPE-A RECEPTOR'''
===SOLUTION CONFORMATION OF AN ATRIAL NATRIURETIC PEPTIDE VARIANT SELECTIVE FOR THE TYPE-A RECEPTOR===




==Overview==
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Two-dimensional NMR spectroscopy has been used to characterize the solution conformation of an atrial natriuretic peptide (ANP) variant which is selective for the human natriuretic peptide receptor A (NPR-A) relative to receptor C (NPR-C). The ANP mutant, containing six substitutions, has reduced flexibility in aqueous solution relative to wild-type ANP and allows the observation of sufficient NOE connectivities for structure determination by distance geometry and restrained molecular dynamics calculations. The solution conformation is reasonably well defined, having an average backbone atom rms deviation from the average coordinates of approximately 1.1 A for residues 7-27. The structure is consistent with available functional data and shows a spatial separation between known receptor binding determinants and residues found to be outside the hormone-receptor interface.
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{{ABSTRACT_PUBMED_8043577}}


==About this Structure==
==About this Structure==
1ANP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ANP OCA].  
1ANP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ANP OCA].  


==Reference==
==Reference==
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[[Category: Mcdowell, R S.]]
[[Category: Mcdowell, R S.]]
[[Category: Hypotensive hormone]]
[[Category: Hypotensive hormone]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:29:06 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:13:38 2008''

Revision as of 14:13, 30 June 2008

File:1anp.png

Template:STRUCTURE 1anp

SOLUTION CONFORMATION OF AN ATRIAL NATRIURETIC PEPTIDE VARIANT SELECTIVE FOR THE TYPE-A RECEPTOR

Template:ABSTRACT PUBMED 8043577

About this Structure

1ANP is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution conformation of an atrial natriuretic peptide variant selective for the type A receptor., Fairbrother WJ, McDowell RS, Cunningham BC, Biochemistry. 1994 Aug 2;33(30):8897-904. PMID:8043577

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