4zzy: Difference between revisions

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<StructureSection load='4zzy' size='340' side='right'caption='[[4zzy]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='4zzy' size='340' side='right'caption='[[4zzy]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4zzy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZZY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZZY FirstGlance]. <br>
<table><tr><td colspan='2'>[[4zzy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZZY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZZY FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D7N:2-[1-(4,4-DIFLUOROCYCLOHEXYL)-PIPERIDIN-4-YL]-6-FLUORO-3-OXO-2,3-DIHYDRO-1H-ISOINDOLE-4-CARBOXAMIDE'>D7N</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D7N:2-[1-(4,4-DIFLUOROCYCLOHEXYL)-PIPERIDIN-4-YL]-6-FLUORO-3-OXO-2,3-DIHYDRO-1H-ISOINDOLE-4-CARBOXAMIDE'>D7N</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zzx|4zzx]], [[4zzz|4zzz]], [[5a00|5a00]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zzy OCA], [https://pdbe.org/4zzy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zzy RCSB], [https://www.ebi.ac.uk/pdbsum/4zzy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zzy ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zzy OCA], [http://pdbe.org/4zzy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zzy RCSB], [http://www.ebi.ac.uk/pdbsum/4zzy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zzy ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PARP2_HUMAN PARP2_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.  
[https://www.uniprot.org/uniprot/PARP2_HUMAN PARP2_HUMAN] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Borghi, D]]
[[Category: Borghi D]]
[[Category: Busel, A A]]
[[Category: Busel AA]]
[[Category: Caprera, F]]
[[Category: Caprera F]]
[[Category: Casale, E]]
[[Category: Casale E]]
[[Category: Ciomei, M]]
[[Category: Ciomei M]]
[[Category: Cirla, A]]
[[Category: Cirla A]]
[[Category: Corti, E]]
[[Category: Corti E]]
[[Category: DAnello, M]]
[[Category: DAnello M]]
[[Category: Donati, D]]
[[Category: Donati D]]
[[Category: Fasolini, M]]
[[Category: Fasolini M]]
[[Category: Felder, E R]]
[[Category: Felder ER]]
[[Category: Forte, B]]
[[Category: Forte B]]
[[Category: Galvani, A]]
[[Category: Galvani A]]
[[Category: Isacchi, A]]
[[Category: Isacchi A]]
[[Category: Khvat, A]]
[[Category: Khvat A]]
[[Category: Krasavin, M Y]]
[[Category: Krasavin MY]]
[[Category: Lupi, R]]
[[Category: Lupi R]]
[[Category: Montagnoli, A]]
[[Category: Montagnoli A]]
[[Category: Orsini, P]]
[[Category: Orsini P]]
[[Category: Papeo, G]]
[[Category: Papeo G]]
[[Category: Perego, R]]
[[Category: Perego R]]
[[Category: Pesenti, E]]
[[Category: Pesenti E]]
[[Category: Pezzetta, D]]
[[Category: Pezzetta D]]
[[Category: Posteri, H]]
[[Category: Posteri H]]
[[Category: Rainoldi, S]]
[[Category: Rainoldi S]]
[[Category: RiccardiSirtori, F]]
[[Category: RiccardiSirtori F]]
[[Category: Scolaro, A]]
[[Category: Scolaro A]]
[[Category: Sola, F]]
[[Category: Sola F]]
[[Category: Zuccotto, F]]
[[Category: Zuccotto F]]
[[Category: Transferase]]