1hbs: Difference between revisions
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New page: left|200px<br /> <applet load="1hbs" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hbs, resolution 3.0Å" /> '''REFINED CRYSTAL STRU... |
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==Overview== | ==Overview== | ||
The crystal structure of deoxyhemoglobin S has been refined at 3.0-A, resolution using the Hendrickson-Konnert restrained least-squares method., Comparison with the structure of deoxyhemoglobin A reveals a hingelike, movement of the beta-chain A helices, which are involved in molecular, contacts, toward the EF corners of their respective subunits. This, movement brings the amino termini of the beta-chains closer to the, molecular dyad. The A helices remain alpha-helical throughout their entire, lengths. No other major structural difference is found between, deoxyhemoglobin A and deoxyhemoglobin S. | The crystal structure of deoxyhemoglobin S has been refined at 3.0-A, resolution using the Hendrickson-Konnert restrained least-squares method., Comparison with the structure of deoxyhemoglobin A reveals a hingelike, movement of the beta-chain A helices, which are involved in molecular, contacts, toward the EF corners of their respective subunits. This, movement brings the amino termini of the beta-chains closer to the, molecular dyad. The A helices remain alpha-helical throughout their entire, lengths. No other major structural difference is found between, deoxyhemoglobin A and deoxyhemoglobin S. | ||
==Disease== | |||
Known diseases associated with this structure: Erythremias, alpha- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141800 141800]], Erythremias, beta- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141900 141900]], Erythrocytosis OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141850 141850]], HPFH, deletion type OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141900 141900]], Heinz body anemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141850 141850]], Heinz body anemias, alpha- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141800 141800]], Heinz body anemias, beta- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141900 141900]], Hemoglobin H disease OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141850 141850]], Hypochromic microcytic anemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141850 141850]], Methemoglobinemias, alpha- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141800 141800]], Methemoglobinemias, beta- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141900 141900]], Sickle cell anemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141900 141900]], Thalassemia, alpha- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141850 141850]], Thalassemia-beta, dominant inclusion-body OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141900 141900]], Thalassemias, alpha- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141800 141800]], Thalassemias, beta- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141900 141900]] | |||
==About this Structure== | ==About this Structure== | ||
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[[Category: oxygen transport]] | [[Category: oxygen transport]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 17:15:20 2007'' | ||
