6w2b: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6w2b is ~~ON HOLD~~

==Anomalous bromine signal reveals the position of Br-paroxetine complexed with the serotonin transporter at the central site==

~~Authors~~: ~~Coleman~~, J.A., ~~Navratna~~, V., ~~Yang~~, D.

== Structural highlights ==

<table><tr><td colspan='2'>[[6w2b]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6W2B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6W2B FirstGlance]. <br>

~~Description~~: ~~Anomalous bromine signal reveals~~ the ~~position~~ of Br-~~paroxetine complexed with~~ the serotonin ~~transporter at~~ the ~~central site~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=RFS:Br-paroxetine'>RFS</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6w2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6w2b OCA], [http://pdbe.org/6w2b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6w2b RCSB], [http://www.ebi.ac.uk/pdbsum/6w2b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6w2b ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/SC6A4_HUMAN SC6A4_HUMAN]] Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.<ref>PMID:17506858</ref> <ref>PMID:18227069</ref> <ref>PMID:19270731</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Coleman, J A]]

[[Category: Navratna, V]]

[[Category: Yang, D]]

[[Category: ~~Navratna, V~~]]

[[Category: Antibody]]

[[Category: ~~Coleman, J.A~~]]

[[Category: Antidepressant]]

[[Category: Complex]]

[[Category: Transport protein]]

[[Category: Transporter]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6w2b is ON HOLD
+==Anomalous bromine signal reveals the position of Br-paroxetine complexed with the serotonin transporter at the central site==
+<StructureSection load='6w2b' size='340' side='right'caption='[[6w2b]], [[Resolution|resolution]] 4.70&Aring;' scene=''>
-Authors: Coleman, J.A., Navratna, V., Yang, D.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6w2b]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6W2B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6W2B FirstGlance]. <br>
-Description: Anomalous bromine signal reveals the position of Br-paroxetine complexed with the serotonin transporter at the central site
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=RFS:Br-paroxetine'>RFS</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6w2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6w2b OCA], [http://pdbe.org/6w2b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6w2b RCSB], [http://www.ebi.ac.uk/pdbsum/6w2b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6w2b ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/SC6A4_HUMAN SC6A4_HUMAN]] Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.<ref>PMID:17506858</ref> <ref>PMID:18227069</ref> <ref>PMID:19270731</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Coleman, J A]]
+[[Category: Navratna, V]]
 [[Category: Yang, D]]
-[[Category: Navratna, V]]
+[[Category: Antibody]]
-[[Category: Coleman, J.A]]
+[[Category: Antidepressant]]
+[[Category: Complex]]
+[[Category: Transport protein]]
+[[Category: Transporter]]