1ar9: Difference between revisions

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[[Image:1ar9.~~gif~~|left|200px]]

[[Image:1ar9.png|left|200px]]

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~~'''~~P1/MAHONEY POLIOVIRUS, SINGLE SITE MUTANT H2142Y~~'''~~

===P1/MAHONEY POLIOVIRUS, SINGLE SITE MUTANT H2142Y===

~~==Overview==~~

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~~In order~~ to ~~better understand~~ the ~~process of cell entry for non-enveloped viruses, we have solved the crystal structures of five poliovirus mutants which can infect cells expressing mutant poliovirus receptors~~. ~~Four of these structures have been solved from frozen crystals using cryocrystallographic data collection methods~~. ~~The mutations have a range of structural consequences~~, ~~from small local perturbations to significant loop rearrangements~~. All of the mutant viruses are more labile to conversion to an apparent cell entry intermediate, suggesting that these mutant viruses could compensate for the suboptimal receptors by lowering the thermal energy required to undergo the receptor-~~mediated conformational change.~~

The line below this paragraph, {{ABSTRACT_PUBMED_9253417}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 9253417 is the PubMed ID number.

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==About this Structure==

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[[Category: Picornavirus]]

[[Category: Poliovirus]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 10~~:36:51 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:27:28 2008''

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-[[Image:1ar9.gif|left|200px]]
+{{Seed}}
+[[Image:1ar9.png|left|200px]]
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 {{STRUCTURE_1ar9|  PDB=1ar9  |  SCENE=  }}
-'''P1/MAHONEY POLIOVIRUS, SINGLE SITE MUTANT H2142Y'''
+===P1/MAHONEY POLIOVIRUS, SINGLE SITE MUTANT H2142Y===
-==Overview==
+<!--
-In order to better understand the process of cell entry for non-enveloped viruses, we have solved the crystal structures of five poliovirus mutants which can infect cells expressing mutant poliovirus receptors. Four of these structures have been solved from frozen crystals using cryocrystallographic data collection methods. The mutations have a range of structural consequences, from small local perturbations to significant loop rearrangements. All of the mutant viruses are more labile to conversion to an apparent cell entry intermediate, suggesting that these mutant viruses could compensate for the suboptimal receptors by lowering the thermal energy required to undergo the receptor-mediated conformational change.
+The line below this paragraph, {{ABSTRACT_PUBMED_9253417}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9253417 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_9253417}}
 ==About this Structure==
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 [[Category: Picornavirus]]
 [[Category: Poliovirus]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:36:51 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:27:28 2008''