1aro: Difference between revisions

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[[Image:1aro.~~jpg~~|left|200px]]

[[Image:1aro.png|left|200px]]

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~~'''~~T7 RNA POLYMERASE COMPLEXED WITH T7 LYSOZYME~~'''~~

===T7 RNA POLYMERASE COMPLEXED WITH T7 LYSOZYME===

~~==Overview==~~

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The T7 RNA polymerase-T7 lysozyme complex regulates phage gene expression during infection of Escherichia coli. The 2.8 A crystal structure of the complex reveals that lysozyme binds at a site remote from the polymerase active site, ~~suggesting an indirect mechanism of inhibition. Comparison of~~ the ~~T7 RNA polymerase structure with that of~~ the ~~homologous pol I family of DNA polymerases reveals identities in the catalytic site but also differences specific to RNA polymerase function~~. ~~The structure of T7 RNA polymerase presented here differs significantly from a previously published structure~~. ~~Sequence similarities between phage RNA polymerases and those from mitochondria and chloroplasts~~, ~~when interpreted in~~ the ~~context of our revised model of T7 RNA polymerase, suggest a conserved fold~~.

The line below this paragraph, {{ABSTRACT_PUBMED_9670025}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 9670025 is the PubMed ID number.

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==About this Structure==

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[[Category: Hydrolase]]

[[Category: Transcription]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 10~~:37:32 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:28:44 2008''

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-[[Image:1aro.jpg|left|200px]]
+{{Seed}}
+[[Image:1aro.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1aro|  PDB=1aro  |  SCENE=  }}
-'''T7 RNA POLYMERASE COMPLEXED WITH T7 LYSOZYME'''
+===T7 RNA POLYMERASE COMPLEXED WITH T7 LYSOZYME===
-==Overview==
+<!--
-The T7 RNA polymerase-T7 lysozyme complex regulates phage gene expression during infection of Escherichia coli. The 2.8 A crystal structure of the complex reveals that lysozyme binds at a site remote from the polymerase active site, suggesting an indirect mechanism of inhibition. Comparison of the T7 RNA polymerase structure with that of the homologous pol I family of DNA polymerases reveals identities in the catalytic site but also differences specific to RNA polymerase function. The structure of T7 RNA polymerase presented here differs significantly from a previously published structure. Sequence similarities between phage RNA polymerases and those from mitochondria and chloroplasts, when interpreted in the context of our revised model of T7 RNA polymerase, suggest a conserved fold.
+The line below this paragraph, {{ABSTRACT_PUBMED_9670025}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9670025 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_9670025}}
 ==About this Structure==
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 [[Category: Hydrolase]]
 [[Category: Transcription]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:37:32 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:28:44 2008''