User:Carson E Middlebrook/Sandbox 1: Difference between revisions
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== Active Site == | == Active Site == | ||
The active site for Bd Oxidase in ''Geobacillus thermodenitrificans'' is located in subunit Cyd A. The site consists of three iron hemes | The active site for Bd Oxidase in ''Geobacillus thermodenitrificans'' is located in subunit Cyd A. The site consists of three iron hemes: Heme B558, Heme B595, and Heme D shown in Fig.1. The three hemes are held together in a rigid triangular arrangement (green link) due to van der wals interactions. The length between each heme's central iron is relatively constant which serves to shuttle protons and electrons from one heme to another efficiently. It is suggested that Heme B558 acts as an electron acceptor to the extracellular side and Heme B559 acts as a proton acceptor on the intracellular side. It is then proposed that both heme B558 and B595 shuttle their respective ions directly to Heme D based on this being the shortest pathway (reference). Heme D is then suggested to be the oxygen binding site due to proximity and orientation to the exterior surface of the protein. | ||
== Relevance == | == Relevance == | ||
