Sandbox Reserved 1606: Difference between revisions
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==Introduction== | ==Introduction== | ||
The [https://en.wikipedia.org/wiki/ABCG2 ABCG2 multidrug transporter] is | The [https://en.wikipedia.org/wiki/ABCG2 ABCG2 multidrug transporter] is a membrane protein from the ATP-binding cassette (ABC) transporter family, specifically the G-subfamily. Also know as the breast cancer resistance protein (BCRP), ABCG2 has physiological roles in various tissue cells including the mammary gland and the blood-brain, bloodtestis, and maternal-fetal barriers.<ref name="Taylor"/> ABCG2 protects cells by exporting xenobiotic molecules out of the cell using ATP hydrolysis. ABCG2 also affects the pharmacokinetics of many drugs and contributes to multidrug resistance.<ref name="Manolaridis"/> | ||
== Function == | == Function == | ||
Transports xenobiotic molecules out of the cell (molecules that shouldn't be there) to protect cellular tissue | Transports xenobiotic molecules out of the cell (molecules that shouldn't be there) to protect cellular tissue (expand a bit/maybe combine intro and function?) | ||
== Structural highlights == | == Structural highlights == | ||
=== | ===Overall 3D Structure=== | ||
===ATP Bound and Unbound Conformations=== | |||
[[Image:bound and unbound.png|400 px|right|thumb|FIGURE LEGEND]] | |||
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===Cavities and Lysine Plug=== | |||
==Disease== | ==Disease== | ||
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== References == | == References == | ||
<ref name="Taylor">PMID:28554189</ref> | <ref name="Taylor">PMID:28554189</ref> | ||
<ref name="Manolaridis">PMID:30405239</ref> | |||
<references/> | <references/> | ||
==Student Contributors | ==Student Contributors== | ||
