1awc: Difference between revisions

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[[Image:1awc.gif|left|200px]]
{{Seed}}
[[Image:1awc.png|left|200px]]


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{{STRUCTURE_1awc|  PDB=1awc  |  SCENE=  }}  
{{STRUCTURE_1awc|  PDB=1awc  |  SCENE=  }}  


'''MOUSE GABP ALPHA/BETA DOMAIN BOUND TO DNA'''
===MOUSE GABP ALPHA/BETA DOMAIN BOUND TO DNA===




==Overview==
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GA-binding protein (GABP) is a transcriptional regulator composed of two structurally dissimilar subunits. The alpha subunit contains a DNA-binding domain that is a member of the ETS family, whereas the beta subunit contains a series of ankyrin repeats. The crystal structure of a ternary complex containing a GABPalpha/beta ETS domain-ankyrin repeat heterodimer bound to DNA was determined at 2. 15 angstrom resolution. The structure shows how an ETS domain protein can recruit a partner protein using both the ETS domain and a carboxyl-terminal extension and provides a view of an extensive protein-protein interface formed by a set of ankyrin repeats. The structure also reveals how the GABPalpha ETS domain binds to its core GGA DNA-recognition motif.
The line below this paragraph, {{ABSTRACT_PUBMED_9461436}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_9461436}}


==About this Structure==
==About this Structure==
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[[Category: Nuclear protein]]
[[Category: Nuclear protein]]
[[Category: Transcription factor]]
[[Category: Transcription factor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:46:29 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:44:28 2008''

Revision as of 14:44, 30 June 2008

File:1awc.png

Template:STRUCTURE 1awc

MOUSE GABP ALPHA/BETA DOMAIN BOUND TO DNA

Template:ABSTRACT PUBMED 9461436

About this Structure

1AWC is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA., Batchelor AH, Piper DE, de la Brousse FC, McKnight SL, Wolberger C, Science. 1998 Feb 13;279(5353):1037-41. PMID:9461436

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