Sandbox Reserved 1613: Difference between revisions
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ABCG2 transports a variety of substrates, particularly flat, hydrophobic, and/or polycylic molecules. It is found in different biological membranes, such as the blood-brain barrier (BBB), blood-testis barrier, and the blood-placental barrier. It is thought to help protect those tissues and many others from cytotoxins. In addition to cytotoxin protection, ABCG2 secretes endogenous substrates in the adrenal gland, excretes toxins in the liver and kidneys, and regulates absorption of substrates. | ABCG2 transports a variety of substrates, particularly flat, hydrophobic, and/or polycylic molecules. It is found in different biological membranes, such as the blood-brain barrier (BBB), blood-testis barrier, and the blood-placental barrier. It is thought to help protect those tissues and many others from cytotoxins. In addition to cytotoxin protection, ABCG2 secretes endogenous substrates in the adrenal gland, excretes toxins in the liver and kidneys, and regulates absorption of substrates. | ||
[https://www-sciencedirect-com.ezproxy.butler.edu/science/article/pii/S0304383505003538] | [https://www-sciencedirect-com.ezproxy.butler.edu/science/article/pii/S0304383505003538 4] | ||
== Disease == | == Disease == | ||
Multidrug resistant cancers are due to ABCG2 excreting cancer drugs out of the cell before they have the chance to kill the cell. Some of these cancers include breast, ovarian, and lung. | Multidrug resistant cancers are due to ABCG2 excreting cancer drugs out of the cell before they have the chance to kill the cell. Some of these cancers include breast, ovarian, and lung. | ||
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[https://www.nature.com/articles/s41594-018-0049-1 Nature_Structural_&_Molecular_Biology_Vol_25] | [https://www.nature.com/articles/s41594-018-0049-1 Nature_Structural_&_Molecular_Biology_Vol_25] | ||
[https://www.nature.com/articles/s41586-018-0680-3] | [https://www.nature.com/articles/s41586-018-0680-3 2] | ||
</StructureSection> | </StructureSection> | ||
