Sandbox Reserved 1626: Difference between revisions
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== Structure == | == Structure == | ||
The precise identity of the MCU as the major calcium transporter remained elusive until 2011. Thanks to a series of combined efforts involving [https://en.wikipedia.org/wiki/Nuclear_magnetic_resonance_spectroscopy NMR spectroscopy], cry-EM, and | The precise identity of the MCU as the major calcium transporter remained elusive until 2011. Thanks to a series of combined efforts involving [https://en.wikipedia.org/wiki/Nuclear_magnetic_resonance_spectroscopy NMR spectroscopy], cry-EM, and [https://en.wikipedia.org/wiki/X-ray_crystallography x-ray crystallography] they were able to see the structure of the membrane-bound transporter and its regulatory machinery. <ref name="Woods"/> The actual MCU complex is a tetrameric <scene name='83/832952/Dimer_of_dimers/3'>dimer of dimers</scene> assembly. As show in the 3D image to the right. What the 3D image does not show is MICU1 and MICU 2, which are tight regulators of the MCU-mediated calcium uptake that actual bring in the calcium and move it towards the selectivity filter in the main MCU complex. There are three other proteins in the complete complex. EMRE, MCUb, and MCUR1. The EMRE is what associates MICU1 and MICU2 with main MCU protein. The MCUR1 has never been truly determined as to what it does for the structure but scientists are saying it helps with building of the overall structure and is non functional once the MCU becomes functional. <ref name="Giorgi" /> | ||
=== Selectivity Filter === | === Selectivity Filter === | ||
