Sandbox Reserved 1607: Difference between revisions
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===Types 1 and 2 Diabetes=== | ===Types 1 and 2 Diabetes=== | ||
Pancreatic [https://en.wikipedia.org/wiki/Beta_cell beta cells] circulate insulin through the body. Glucose initiates signals allowing these cells to break down sugar and release insulin, which is all stimulated by mitochondrial energy metabolism. Calcium homeostasis plays a fundamental role in ATP production supplying energy to this process. Defects in homeostasis of calcium like chronic calcium depletion, caused by leaky Ryanodine receptors, causes types 1 and 2 diabetes through failure of this mechanism. Treatment involves targeting the MCU and MICU1 to open the calcium channel and allow more uptake of calcium ions into the mitochondria. | Pancreatic [https://en.wikipedia.org/wiki/Beta_cell beta cells] circulate insulin through the body. Glucose initiates signals allowing these cells to break down sugar and release insulin, which is all stimulated by mitochondrial energy metabolism. Calcium homeostasis plays a fundamental role in ATP production supplying energy to this process. Defects in homeostasis of calcium like chronic calcium depletion, caused by leaky [https://en.wikipedia.org/wiki/Ryanodine_receptor Ryanodine receptors], causes types [https://en.wikipedia.org/wiki/Type_1_diabetes 1] and [https://en.wikipedia.org/wiki/Type_2_diabetes 2] diabetes through failure of this mechanism. Treatment involves targeting the MCU and MICU1 to open the calcium channel and allow more uptake of calcium ions into the mitochondria. | ||
===Heart Failure=== | ===Heart Failure=== | ||
